Active Proteins

AAA Biotech provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.

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Application Data

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BMP-2, Active Protein (Cat# AAA79170)

Full Name

Human BMP-2

Gene Names

BMP2; BDA2; BMP2A

Reactivity

Human

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$355/0.005 mg $685/2x0.005 mg $995/3x0.005 mg $1,235/5x0.005 mg $1,295/4x0.005 mg

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Application Data

Application Data

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VEGF120, Active Protein (Cat# AAA79175)

Full Name

Rat VEGF120

Gene Names

Vegfa; VPF; Vegf; VEGF-A; VEGF164

Reactivity

Rat

Purity

>95%, by SDS-PAGE and silver stain

Pricing

$305/0.002 mg $585/2x0.002 mg $850/3x0.002 mg $1,010/5x0.002 mg $1,105/4x0.002 mg

SDS-PAGE ((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)

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Angiotensin-Converting Enzyme 2 (ACE2), Active Protein (Cat# AAA235619)

Full Name

Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2), Partial

Gene Names

ACE2; ACEH

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Pricing

$380/0.01 mg $875/0.05 mg $2,745/0.5 mg $3,865/1 mg $7,530/2x1 mg $11,005/3x1 mg $14,290/4x1 mg $17,500/5x1 mg

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Application Data (Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers. Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate is combined with 100 uM of active alpha Synuclein monomer, as compared to when 100 uM of active alpha Synuclein monomer is combined with 10 nM of control alpha Synuclein aggregate, or 100 uM of control alpha Synuclein monomer is combined with 10 nM of control alpha Synuclein aggregate. Thioflavin T ex = 450 nm, em = 485 nm.)

Application Data (Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 ug/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 ug/ml (A-C). Tissue: Primary hippocampal neurons. Species: Sprague-Dawley rat. Fixation: 4% formaldehyde made from PFA. Primary Antibody: Mouse anti-pSer129 Antibody at 1:1000 24 hours at 4 degree C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:700 for 1 hours at RT. Counterstain: Hoechst (blue) nuclear stain at 1:4000 for 1 hour at RT. Localization: Lewy body incluscions. Magnification: 20x.)

SDS-PAGE (SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Aggregate. Lane 1: Molecular Weight Ladder (MW). Lane 2: Alpha Synuclein Protein Aggregate (SPR-317).)

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Alpha Synuclein, Active Protein (Cat# AAA253922)

Full Name

Alpha Synuclein Protein

Gene Names

SNCA; PD1; NACP; PARK1; PARK4

Applications

Western Blot

Purity

Ion-exchange Purified

Pricing

$630/0.1 mg $890/2x0.1 mg $1,620/5x0.1 mg

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SDS-PAGE (SDS-PAGE of ~14 kDa Active Human Recombinant Alpha Synuclein Protein Aggregate. Lane 1: Molecular Weight Ladder (MW). Lane 2: Active Alpha Synuclein Protein Aggregate.)

Application Data (Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers. Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate is combined with 100 uM of active alpha Synuclein monomer, as compared to active alpha Synuclein aggregate and active alpha Synuclein monomer alone. Thioflavin T ex = 450 nm, em = 485 nm.)

Application Data (Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 ug/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 ug/ml (A-C). Tissue: Primary hippocampal neurons. Species: Sprague-Dawley rat. Fixation: 4% formaldehyde from PFA. Primary Antibody: Mouse anti-pSer129 Antibody at 1:1000 24 hours at 4 degree C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:700 for 1 hours at RT. Counterstain: Hoechst (blue) nuclear stain at 1:4000 for 1 hour at RT. Localization: Lewy body incluscions. Magnification: 20x.)

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Alpha Synuclein, Active Protein (Cat# AAA253923)

Full Name

Alpha Synuclein Protein

Gene Names

SNCA; PD1; NACP; PARK1; PARK4

Applications

Western Blot

Purity

>95%
Ion-exchange Purified

Pricing

$630/0.1 mg $890/2x0.1 mg $1,620/5x0.1 mg

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SDS-PAGE (SDS-PAGE of ~14 kDa Active Mouse Recombinant Alpha Synuclein Protein Monomer (SPR-323). Lane 1: Molecular Weight Ladder (MW). Lane 2: Active Alpha Synuclein Protein Monomer (2 ug) (SPR-323).)

Application Data (Active alpha synuclein aggregate (SPR-324) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-323). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-324) is combined with 100 uM of active alpha Synuclein monomer (SPR-323), as compared to active alpha Synuclein aggregate (SPR-324) and active alpha Synuclein monomer (SPR-323) alone. Thioflavin T ex = 450 nm, em = 485 nm.)

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Alpha Synuclein, Active Protein (Cat# AAA253924)

Full Name

Alpha Synuclein Protein

Gene Names

Snca; NACP; alphaSYN; alpha-Syn

Applications

Western Blot

Purity

>95%
Ion-exchange Purified

Pricing

$630/0.1 mg $890/2x0.1 mg $1,620/5x0.1 mg

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Bioactivity (Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 5 ug/ml can bind human ACE2 , the EC50 of SARS-CoV-2-S1-RBD protein is 115.0 - 274.9 ng/ml)

Bioactivity (Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 2 ?g/ml can bind SARS-CoV-2-S Antibody , the EC50 of SARS-CoV-2-S1-RBD protein is 13.96 -16.62 ng/ml)

Bioactivity (Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 2 ?g/ml can bind SARS-CoV-2-S Antibody , the EC50 of SARS-CoV-2-S1-RBD protein is 27.96 - 33.35 ng/ml.)

SDS-PAGE ((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Predicted band size: 30.1 kDa Observed band size: 35 kDa due to glycosylation)

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COVID 19 Spike glycoprotein (S) Coronavirus, Active Protein (Cat# AAA243745)

Full Name

Recombinant Human Novel Coronavirus Spike glycoprotein (S), partial

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Pricing

$335/0.02 mg $740/0.1 mg $4,150/1 mg $8,090/2x1 mg $11,820/3x1 mg $15,345/4x1 mg $18,710/5x1 mg

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Bioactivity

SDS-PAGE ((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)

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CD40 ligand (CD40LG), Active Protein (Cat# AAA244028)

Full Name

Recombinant Human CD40 ligand (CD40LG), partial

Gene Names

CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Pricing

$325/0.02 mg $505/0.1 mg $3,370/1 mg $6,565/2x1 mg $9,595/3x1 mg $12,455/4x1 mg $15,255/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human EphB4-his at 2 ug/ml (100 ul/well) can bind human EphrinB2 Fc chimera with a linear range of 1-25 ng/ml.)

SDS-PAGE

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Ephrin B2, Active Protein (Cat# AAA257941)

Full Name

Ephrin B2 Protein, Human, Recombinant (His & hFc Tag)

Gene Names

EFNB2; HTKL; EPLG5; Htk-L; LERK5

Purity

>97% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human EFNB2 at 10ug/mL (100uL/well) can bind biotinylate human EphB4-Fc, the EC50 of biotinylate human EphB4-Fc is 5-60 ng/mL.)

SDS-PAGE

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Ephrin B2, Active Protein (Cat# AAA257943)

Full Name

Ephrin B2 Protein, Human, Recombinant

Gene Names

EFNB2; HTKL; EPLG5; Htk-L; LERK5

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized mouse EphB3 at 2 ug/ml (100 ul/well) can bind human EFNB1 Fc chimera with a linear ranger of 1.56-25 ng/ml.)

SDS-PAGE

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Ephrin-B1, Active Protein (Cat# AAA257947)

Full Name

Ephrin-B1 Protein, Human, Recombinant (His & hFc Tag)

Gene Names

EFNB1; CFND; CFNS; EFL3; EPLG2; Elk-L; LERK2

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data (Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.1--1 ug/mL in the presence of 2.5 ug/mL of rmKlotho beta.)

SDS-PAGE

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FGF21, Active Protein (Cat# AAA257950)

Full Name

FGF21 Protein, Human, Recombinant (His Tag)

Purity

>95% as determined by SDS-PAGE

Pricing

$325/0.05 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast adenocarcinoma cells (Karey, K.P. et al. (1988) Cancer Research 48:4083.). The ED50 for this effect is typically 0.04-0.4 ug/mL in the presence of 14 ng/mL human IGFII.)

SDS-PAGE

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IGFBP4, Active Protein (Cat# AAA257955)

Full Name

IGFBP4 Protein, Human, Recombinant (His Tag)

Gene Names

IGFBP4; BP-4; IBP4; IGFBP-4; HT29-IGFBP

Purity

>95% as determined by SDS-PAGE

Pricing

$490/0.1 mg $2,690/1 mg $5,240/2x1 mg $7,660/3x1 mg $9,935/4x1 mg $11,900/5x1 mg

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Application Data (Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is typically 0.01-0.04 ug/mL.)

SDS-PAGE

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Transferrin, Active Protein (Cat# AAA257958)

Full Name

Transferrin Protein, Human, Recombinant (His Tag)

Gene Names

TF; TFQTL1; PRO1557; PRO2086

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human CD7-His at 10 ug/ml (100 ul /well) can bind biotinylated SECTM1-His, The EC50 of biotinylated SECTM1-His is 11-26ng/ml.)

SDS-PAGE

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CD7, Active Protein (Cat# AAA257959)

Full Name

CD7 Protein, Human, Recombinant (His Tag)

Gene Names

CD7; GP40; TP41; Tp40; LEU-9

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,710/1 mg $5,280/2x1 mg $7,715/3x1 mg $10,015/4x1 mg $12,010/5x1 mg

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Application Data (Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-0.8 ug/ml in the presence of 10 ng/mL of Recombinant human NGF.)

SDS-PAGE

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TrkA, Active Protein (Cat# AAA257961)

Full Name

TrkA Protein, Human, Recombinant (aa 285-413, His Tag)

Gene Names

NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

Purity

>97% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1 ug/ml (100 ul/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml.)

SDS-PAGE

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CD200R, Active Protein (Cat# AAA257969)

Full Name

CD200R Protein, Human, Recombinant (His & hFc Tag)

Gene Names

CD200R1; OX2R; MOX2R; CD200R; HCRTR2

Purity

>94% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human EPHA3-His at 10 ug/ml (100 ul/well) can bind human EphrinA5-Fc, The EC50 of human EphrinA5-Fc is 6.2-14.6 ng/ml.)

SDS-PAGE

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EphA3, Active Protein (Cat# AAA257975)

Full Name

EphA3 Protein, Human, Recombinant (His Tag)

Gene Names

EPHA3; EK4; ETK; HEK; ETK1; HEK4; TYRO4

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 1-6 ng/mL.)

SDS-PAGE

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FGF6, Active Protein (Cat# AAA257976)

Full Name

FGF6 Protein, Human, Recombinant

Gene Names

FGF6; HST2; HBGF-6

Purity

>95% as determined by SDS-PAGE

Pricing

$230/0.02 mg $555/0.1 mg $2,840/1 mg $5,535/2x1 mg $8,085/3x1 mg $10,495/4x1 mg $12,575/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human human B7-H2 at 1 ug/ml (100 ul/well) can bind human ICOS with a linear range of 1.6-200 ng/ml.)

SDS-PAGE

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ICOS ligand, Active Protein (Cat# AAA257977)

Full Name

ICOS ligand Protein, Human, Recombinant (ECD, His Tag)

Gene Names

ICOSLG; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

Purity

>98% as determined by SDS-PAGE

Pricing

$325/0.1 mg $1,565/1 mg $3,045/2x1 mg $4,455/3x1 mg $5,780/4x1 mg $6,835/5x1 mg

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Application Data (1. Immobilized Human ERBB3 His at 2 ug/ml (100 ul/well) can bind Human NRG1 Fc, the EC50 of Human NRG1 Fc is 8-40 ng/mL. 2. Immobilized Rhesus ERBB3 His at 2 ug/ml (100 ul/well) can bind Human NRG1 Fc, the EC50 of Human NRG1 Fc is 20-80 ng/mL.)

SDS-PAGE

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NRG1 Beta 1, Active Protein (Cat# AAA257981)

Full Name

NRG1 Beta 1 Protein, Human, Recombinant (ECD, Fc Tag)

Gene Names

NRG1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131

Purity

>85% as determined by SDS-PAGE

Pricing

$310/0.1 mg $595/2x0.1 mg $865/3x0.1 mg $1,120/4x0.1 mg $1,175/5x0.1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human SIRPA-His at 10 ug/ml (100 ul/well) can bind human CD47-Fc, The EC50 of human CD47-Fc is 10.1-23.5 ng/ml.)

SDS-PAGE

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SIRP alpha, Active Protein (Cat# AAA257985)

Full Name

SIRP alpha Protein, Human, Recombinant (G75A, ECD, His Tag)

Gene Names

SIRPA; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

Purity

>98% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,295/1 mg $4,480/2x1 mg $6,540/3x1 mg $8,495/4x1 mg $10,130/5x1 mg

SDS-PAGE

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RAGE, Active Protein (Cat# AAA257986)

Full Name

RAGE Protein, Human, Recombinant (His Tag)

Gene Names

AGER; RAGE; SCARJ1

Purity

>98% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human SIRPG-His at 10 ug/ml (100 ul/well) can bind human CD47-Fc, The EC50 of human CD47-Fc is 0.58-1.34 ug/ml.)

SDS-PAGE

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SIRP gamma/SIRPG, Active Protein (Cat# AAA257993)

Full Name

SIRP gamma/SIRPG Protein, Human, Recombinant (ECD, His Tag)

Gene Names

SIRPG; CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma

Purity

>96% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human EPHB1-His at 10 ug/ml (100 ul/well) can bind human EFNB2-Fch with a linear ranger of 0.3125-20 ng/mL.)

Application Data (Measured by its binding ability in a functional ELISA. Immobilized human EPHB1-His at 10 ug/ml (100 ul/well) can bind human EFNB1-Fc2h with a linear ranger of 3.125-200 ng/mL.)

SDS-PAGE

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EphB1, Active Protein (Cat# AAA257999)

Full Name

EphB1 Protein, Human, Recombinant (His Tag)

Gene Names

EPHB1; ELK; NET; Hek6; EPHT2

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.05 mg $850/2x0.05 mg $1,235/3x0.05 mg $1,605/4x0.05 mg $1,755/5x0.05 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human CADM1 at 2 ug/ml (100 ul/well) can bind biotinylated human CRTAM with a linear range of 12.5-400 ng/ml.)

SDS-PAGE

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CRTAM, Active Protein (Cat# AAA258000)

Full Name

CRTAM Protein, Human, Recombinant (His Tag)

Gene Names

CRTAM; CD355

Purity

>94% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data

Application Data

Application Data (Using the Octet RED System, the affinity constant (Kd) of CD32B / Fcgr2b Protein, Human, Recombinant (His Tag) bound to Conbercept was 0.3 nM.)

Application Data (Measured by its binding ability in a functional ELISA. Immobilized human sCD32b-His (CHO) at 10 ug/ml (100 ul/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.18-0.42 ug/ml.)

SDS-PAGE

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CD32B/Fcgr2b, Active Protein (Cat# AAA257858)

Full Name

CD32B/Fcgr2b Protein, Human, Recombinant (ECD, His Tag)

Gene Names

FCGR2B; CD32; FCG2; CD32B; FCGR2; IGFR2

Purity

>97% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,295/1 mg $4,480/2x1 mg $6,540/3x1 mg $8,495/4x1 mg $10,130/5x1 mg

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Application Data (Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with mouse Flt-3. The ED50 for this effect is typically 2-11 ng/mL.)

SDS-PAGE

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Flt3 Ligand, Active Protein (Cat# AAA257867)

Full Name

Flt3 Ligand Protein, Human, Recombinant (His Tag)

Gene Names

FLT3LG; FL; FLT3L

Purity

>95% as determined by SDS-PAGE

Pricing

$220/0.01 mg $325/0.05 mg $2,690/1 mg $5,240/2x1 mg $7,660/3x1 mg $9,935/4x1 mg $11,900/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human GFRA1-Fc at 10 ug/mL (100 uL/well) can bind GDNF/Biotin, the EC50 of human GDNF/Biotin is 20-50 ng/mL.)

SDS-PAGE

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GFR Alpha-1/GFRA1, Active Protein (Cat# AAA257871)

Full Name

GFR Alpha-1/GFRA1 Protein, Human, Recombinant (hFc Tag)

Gene Names

GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1

Purity

>90% as determined by SDS-PAGE

Pricing

$490/0.1 mg $955/2x0.1 mg $1,400/3x0.1 mg $1,815/4x0.1 mg $2,015/5x0.1 mg

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Application Data (Measured by its ability to inhibit rhIFN-gamma mediated protection of WISH cells infected with vesicular stomatitis virus(VSV). The ED50 for this effect is typically 2-8 ug/mL.)

SDS-PAGE

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IFNGR1, Active Protein (Cat# AAA257873)

Full Name

IFNGR1 Protein, Human, Recombinant (His Tag)

Gene Names

IFNGR1; CD119; IFNGR

Purity

>97% as determined by SDS-PAGE

Pricing

$325/0.1 mg $1,565/1 mg $3,045/2x1 mg $4,455/3x1 mg $5,780/4x1 mg $6,835/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human human B7-H2 at 1 ug/ml (100 ul/well) can bind human ICOS with a linear range of 1.6-200 ng/ml.)

SDS-PAGE

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ICOS, Active Protein (Cat# AAA257874)

Full Name

ICOS Protein, Human, Recombinant (His & hFc Tag)

Gene Names

ICOS; AILIM; CD278; CVID1

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 ug/mL (100 uL/well) can bind TGFB1-His/Biotin, the EC50 of human TGFB1-His/Biotin is 130-300 ng/mL.)

SDS-PAGE

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TGFBR2, Active Protein (Cat# AAA257875)

Full Name

TGFBR2 Protein, Human, Recombinant (ECD, hFc Tag)

Gene Names

TGFBR2; AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII

Purity

>95% as determined by SDS-PAGE

Pricing

$325/0.05 mg $625/2x0.05 mg $910/3x0.05 mg $1,180/4x0.05 mg $1,245/5x0.05 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized PPICZa-IFNA2 at 10 ug/mL (100 uL/well) can bind IFNaR2-Fc, the EC50 of IFNaR2-Fc is 60-200 ng/mL.)

SDS-PAGE

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IFNAR2, Active Protein (Cat# AAA257877)

Full Name

IFNAR2 Protein, Human, Recombinant (hFc Tag)

Gene Names

IFNAR2; IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al. (1997) Biochem. Biophys. Res. Commun.237:465. The ED50 for this effect is typically 2-10 ug/mL.)

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Sonic Hedgehog, Active Protein (Cat# AAA257878)

Full Name

Sonic Hedgehog Protein, Human, Recombinant (aa 1-197, His Tag)

Gene Names

SHH; TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5

Purity

>95% as determined by SDS-PAGE

Pricing

$265/0.02 mg $490/0.1 mg $2,670/1 mg $5,200/2x1 mg $7,595/3x1 mg $9,860/4x1 mg $11,800/5x1 mg

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Application Data (Measured by its ability to inhibit TNF-alpha mediated cytotoxicity in L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 5-40 ng/mL in the presence of 1 ng/mL recombinant human TNF-alpha.)

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TNFR2/TNFRSF1B, Active Protein (Cat# AAA257881)

Full Name

TNFR2/TNFRSF1B Protein, Human, Recombinant (aa 1-268, 196 Met/Arg, His Tag)

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.5-2.5 ng/ml.)

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Oncostatin M/OSM, Active Protein (Cat# AAA257885)

Full Name

Oncostatin M/OSM Protein, Human, Recombinant (His Tag)

Purity

>95% as determined by SDS-PAGE

Pricing

$490/0.1 mg $2,680/1 mg $5,220/2x1 mg $7,625/3x1 mg $9,895/4x1 mg $11,850/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized PDGFRbeta-His at 10 ug/ml (100 ul/well) can bind Cynomolgus PDGFB, The EC50 of Cynomolgus PDGFB is 3-8 ng/ml.)

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PDGFRB, Active Protein (Cat# AAA257890)

Full Name

PDGFRB Protein, Human, Recombinant (His Tag)

Gene Names

PDGFRB; IBGC4; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1

Purity

>90% as determined by SDS-PAGE

Pricing

$375/0.1 mg $1,945/1 mg $3,785/2x1 mg $5,535/3x1 mg $7,185/4x1 mg $8,540/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human BMPR-II-Fc at 10 ug/mL (100 ul/well) can bind biotinylated human BMP2-Fc, The EC50 of biotinylated human BMP2-Fc is 80-110 ng/mL.)

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BMPR2, Active Protein (Cat# AAA257894)

Full Name

BMPR2 Protein, Human, Recombinant (His & hFc Tag)

Gene Names

BMPR2; BMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II

Purity

>90% as determined by SDS-PAGE

Pricing

$610/0.2 mg $1,180/2x0.2 mg $1,725/3x0.2 mg $2,235/4x0.2 mg $2,530/5x0.2 mg

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Application Data (Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGFR2b. The EC50 for this effect is typically 2-14 ng/mL.)

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FGF10, Active Protein (Cat# AAA257898)

Full Name

FGF10 Protein, Human, Recombinant

Purity

>95% as determined by SDS-PAGE

Pricing

$265/0.02 mg $555/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized Human IGF1 at 2 ug/ml (100 ul/well) can bind Human IGFBP4 His, the EC50 of Human IGFBP4 His is 10-60 ng/mL.)

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IGF1, Active Protein (Cat# AAA257900)

Full Name

IGF1 Protein, Human, Recombinant

Gene Names

IGF1; IGFI; IGF-I; IGF1A

Purity

>95% as determined by SDS-PAGE

Pricing

$180/0.1 mg $295/1 mg $565/2x1 mg $820/3x1 mg $1,065/4x1 mg $1,115/5x1 mg

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Application Data (Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 1-5 ng/mL.)

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TNF-alpha, Active Protein (Cat# AAA257901)

Full Name

TNF-alpha Protein, Human, Recombinant (hFc Tag)

Gene Names

TNF; DIF; TNFA; TNFSF2; TNF-alpha

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to bind human LIF-Fc in a functional ELISA.)

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LIFR, Active Protein (Cat# AAA257904)

Full Name

LIFR Protein, Human, Recombinant (His Tag)

Gene Names

LIFR; SWS; SJS2; STWS; CD118; LIF-R

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.5-3 ug/mL in the presence of 10 ng/ml Recombinant Human ctivin A.)

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Follistatin, Active Protein (Cat# AAA257910)

Full Name

Follistatin Protein, Human, Recombinant (hFc Tag)

Gene Names

FST; FS

Purity

>85% as determined by SDS-PAGE

Pricing

$375/0.05 mg $1,690/0.5 mg $3,290/2x0.5 mg $4,805/3x0.5 mg $6,240/4x0.5 mg $7,410/5x0.5 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized recombinant human Angiopoietin-2 at 10 ug/ml (100 ul/well) can bind Human Tie2 / Fc chimera with a range of 0.2-20 ug/ml.)

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TIE2, Active Protein (Cat# AAA257917)

Full Name

TIE2 Protein, Human, Recombinant (ECD, His & hFc Tag)

Gene Names

TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.2 mg $850/2x0.2 mg $1,235/3x0.2 mg $1,605/4x0.2 mg $1,755/5x0.2 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized EPOR (hFc Tag) at 2 ug/mL (100uL/well) can bind Cynomolgus Erythropoietin-His, the EC50 of Cynomolgus Erythropoietin-His is 4-20 ng/mL.)

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EPOR, Active Protein (Cat# AAA257918)

Full Name

EPOR Protein, Human, Recombinant (hFc Tag)

Gene Names

EPOR; EPO-R

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to bind biotinylated human DMP1 in a functional ELISA.)

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Factor H, Active Protein (Cat# AAA257920)

Full Name

Factor H Protein, Human, Recombinant (His Tag)

Gene Names

CFH; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3

Purity

>95% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

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Application Data (Measured by its ability to bind recombinant human EphrinB2 in a functional ELISA.)

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EphB2, Active Protein (Cat# AAA257925)

Full Name

EphB2 Protein, Human, Recombinant (His & hFc Tag)

Gene Names

EPHB2; DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $850/2x0.1 mg $1,235/3x0.1 mg $1,605/4x0.1 mg $1,755/5x0.1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human CD40L-His at 10 ug/mL (100 uL/well) can bind Human CD40-Fc. The EC50 of Human CD40-Fc is 10-30 ng/mL.)

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CD40, Active Protein (Cat# AAA257926)

Full Name

CD40 Protein, Human, Recombinant (ECD, hFc Tag)

Gene Names

CD40; p50; Bp50; CDW40; TNFRSF5

Purity

>90% as determined by SDS-PAGE

Pricing

$385/0.1 mg $2,250/1 mg $4,390/2x1 mg $6,410/3x1 mg $8,320/4x1 mg $9,935/5x1 mg

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Application Data (Measured by its binding ability in a functional ELISA. Immobilized human CD70 at 10 ug/mL (100 ul/well) can bind human CD27 with a linear range of 40-60 ng/ml.)

Application Data (Measured by its binding ability in a functional ELISA. Immobilized human CD70 at 10 ug/mL (100 ul/well) can bind mouse CD27 with a linear range of 70-90 ng/ml.)

Application Data (Measured by its binding ability in a functional ELISA. Immobilized Human CD27 His at 2 ug/ml (100 ul/well) can bind Human CD70 hFc, the EC50 of Human CD70 hFc is 15-60 ng/mL.)

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CD70, Active Protein (Cat# AAA257927)

Full Name

CD70 Protein, Human, Recombinant (hFc Tag)

Gene Names

CD70; CD27L; CD27LG; TNFSF7

Purity

>90% as determined by SDS-PAGE

Pricing

$435/0.1 mg $2,310/1 mg $4,500/2x1 mg $6,570/3x1 mg $8,530/4x1 mg $10,195/5x1 mg

What Are Active Proteins?

Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).

If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.

Key Applications of Active Proteins

1. Scientific Research

• Aid in the study of how proteins function in the body


• Aid in understanding various disease processes

2. Drug Development

• Powerful tools to investigate how potential drugs interact with specific proteins


• Ideal for identifying drug targets

3. Cell Culture

• Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)


• Can be used to promote cellular development into specific types (differentiation)

4. Diagnostics

• Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)


• Note: All products are strictly for research-use only (RUO).

5. Therapeutics

• Some active proteins are used directly as treatments (e.g., insulin, enzymes)


• Note: All products are strictly for research-use only (RUO).

6. Vaccine Development

• Used to create or test vaccines by mimicking parts of viruses or bacteria

7. Biochemical Assays

• They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests

Why Buy Active Proteins from AAA Biotech?

• High biological activity – Verified to perform as expected or indicated on datasheet


• Strict quality control – We are confident in our active proteins’ reliability and consistency


• High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components


• Freeze-dried for stability – Long shelf life and straightforward storage


• Mostly tag-free – Closer to natural/native protein form

FAQ

1. What are active proteins used for in research?

Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.

2. How are AAA Biotech's active proteins validated?

AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.

3. Are these proteins tested for biological activity?

Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.