Active Proteins

AAA Biotech provides a variety of high-quality recombinant and natural/native proteins that are proven to work in a wide range of experiments. Explore our products to find the active protein that best fits your needs or experimental model.

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Bioactivity (HTRF assay for MAP2K1 (MEK1) activity 1 uM TK substrate was incubated with different concentrations of MAP2K1 (MEK1) protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, 5 nM SEB and 100 uM ATP for 1 hour. Then 10 ul detection reagents containing anti-TK antibody and SAXL665 (each of which was 1:100 diluted with 1× Detection Buffer) were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF KinEASE TK assay was used to detect the enzymatic activity.)

SDS-PAGE (Recombinant MAP2K1 (MEK1 protein 10% SDS-PAGE with Coomassie blue staining MW: 46.8 kDa Purity: >80%)

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MAP2K1 (MEK1), Active Protein (Cat# AAA60313)

Full Name

Recombinant MAP2K1 (MEK1) protein

Purity

>80%

Pricing

$715/0.02 mg $5,155/1 mg $10,050/2x1 mg $14,680/3x1 mg $19,060/4x1 mg $22,940/5x1 mg

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Bioactivity (HTRF assay for RPS6KA2/RSK3 protein activity 1 uM STK S1 substrate was incubated with different concentrations of RPS6KA2/RSK3 protein in a 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

Bioactivity (HTRF assay for RPS6KA2/RSK3 protein activity 1 uM STK S1 substrate was incubated with different concentrations of RPS6KA2/RSK3 protein in a 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT, and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

SDS-PAGE (Recombinant RPS6KA2/RSK3 protein 10% SDS-PAGE Coomassie staining MW: 84.5 kDa Purity: >= 90%)

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RPS6KA2/RSK3, Active Protein (Cat# AAA60321)

Full Name

Recombinant RPS6KA2/RSK3 protein

Purity

>=90%

Pricing

$700/0.02 mg $1,365/2x0.02 mg $1,990/3x0.02 mg $2,585/4x0.02 mg $2,920/5x0.02 mg

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Bioactivity (HTRF Assay for Recombinant PRKD2 activity. 1 uM STK S1 substrate was incubated with different concentrations of PRKD2 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

Bioactivity (HTRF Assay for Recombinant PRKD2 activity. 1 uM STK S1 substrate was incubated with different concentrations of PRKD2 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

SDS-PAGE (Recombinant PRKD2 protein gel 10% SDS-PAGE gel with Coomassie blue staining MW: 98 kDa Purity: >80%)

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PRKD2, Active Protein (Cat# AAA60332)

Full Name

Recombinant PRKD2 protein

Purity

>80%

Pricing

$700/0.02 mg $5,155/1 mg $10,050/2x1 mg $14,680/3x1 mg $19,060/4x1 mg $22,940/5x1 mg

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Bioactivity (HTRF Assay for Recombinant PLK1 activity. 1 uM STK S1 substrate was incubated with different concentrations of PLK1 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

Bioactivity (HTRF Assay for Recombinant PLK1 activity. 1 uM STK S1 substrate was incubated with different concentrations of PLK1 protein in 10 ul reaction system containing 1×Enzymatic Buffer, 5 mM MgCl2, 1 mM DTT and 100 uM ATP for 1 hour. The 10 ul detection reagents containing anti-STK antibody (1:2) and SA-XL665 (1:100) diluted with 1× Detection Buffer were added and incubated with the reactions for 30 min. All the operations and reactions were performed at room temperature. HTRF assay was used for detection.)

SDS-PAGE (Recombinant PLK1 protein gel 10% SDS-PAGE gel with Coomassie blue staining MW: 69.5 kDa Purity: >80%)

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PLK1, Active Protein (Cat# AAA60338)

Full Name

Recombinant PLK1 protein

Purity

>80%

Pricing

$700/0.02 mg $1,365/2x0.02 mg $1,990/3x0.02 mg $2,585/4x0.02 mg $2,920/5x0.02 mg

SDS-PAGE (3 ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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Beta-lactaminase, Active Protein (Cat# AAA48963)

Full Name

Beta-lactaminase, E Coli, 20-377, His-tag, E Coli (Bioactivity Validated)

Gene Names

ampC; ampA; ECK4146; JW4111

Applications

Enzyme Activity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$215/0.01 mg $250/0.02 mg $325/0.05 mg $440/0.1 mg $680/0.25 mg $680/5x0.01 mg $860/5x0.02 mg $1,060/0.5 mg $1,140/5x0.05 mg $1,690/5x0.1 mg $2,055/2x0.5 mg $2,770/5x0.25 mg $3,000/3x0.5 mg $3,895/4x0.5 mg $4,450/5x0.5 mg

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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IL15RA, Active Protein (Cat# AAA48968)

Full Name

IL15RA, 31-205aa, Human, hIgG-His-tag, Baculovirus

Gene Names

IL15RA; CD215

Applications

Bioactivity, SDS-PAGE

Purity

> 90% by SDS-PAGE

Pricing

$285/0.01 mg $345/0.02 mg $390/0.05 mg $520/0.1 mg $780/0.25 mg $895/5x0.01 mg $1,160/5x0.02 mg $1,215/0.5 mg $1,375/5x0.05 mg $1,960/5x0.1 mg $2,370/2x0.5 mg $3,140/5x0.25 mg $3,460/3x0.5 mg $4,490/4x0.5 mg $5,110/5x0.5 mg

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Bioactivity (MERS-CoV Spike RBD is coated at 2 ug/ml (100 ul/well) can bind human DPPIV/CD26 in a functional ELISA assay.)

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

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MERS-CoV Spike, Active Protein (Cat# AAA48981)

Full Name

Recombinant MERS-CoV Spike RBD protein

Applications

Bioactivity, SDS-PAGE

Purity

> 90% by SDS-PAGE

Pricing

$275/0.01 mg $355/0.02 mg $415/0.05 mg $600/0.1 mg $905/5x0.01 mg $945/0.25 mg $1,290/5x0.02 mg $1,515/0.5 mg $1,560/5x0.05 mg $2,380/5x0.1 mg $2,955/2x0.5 mg $3,970/5x0.25 mg $4,315/3x0.5 mg $5,605/4x0.5 mg $6,525/5x0.5 mg

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

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Cyclophilin A, Active Protein (Cat# AAA48477)

Full Name

Cyclophilin A, 1-165aa, Human, E Coli (Bioactivity Validated)

Gene Names

PPIA; CYPA; CYPH; HEL-S-69p

Applications

Enzyme Activity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$225/0.02 mg $350/0.1 mg $720/5x0.02 mg $730/0.5 mg $1,255/5x0.1 mg $1,425/2x0.5 mg $2,080/3x0.5 mg $2,700/4x0.5 mg $3,005/5x0.5 mg

SDS-PAGE

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G6PD, Active Protein (Cat# AAA48520)

Full Name

G6PD,1-491aa, E Coli, E Coli (Bioactivity Validated)

Gene Names

zwf; ECK1853; JW1841

Applications

SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$215/0.02 mg $315/0.1 mg $620/0.5 mg $675/5x0.02 mg $1,115/5x0.1 mg $1,200/2x0.5 mg $1,755/3x0.5 mg $2,275/4x0.5 mg $2,485/5x0.5 mg

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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Carbonic anhydrase 2, Active Protein (Cat# AAA48538)

Full Name

Carbonic anhydrase 2, 1-260aa, Human, E Coli (Bioactivity Validated)

Gene Names

CA2; CAC; CAII; Car2; CA-II; HEL-76; HEL-S-282

Applications

Enzyme Activity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$250/0.02 mg $440/0.1 mg $860/5x0.02 mg $1,060/0.5 mg $1,690/5x0.1 mg $2,055/2x0.5 mg $3,000/3x0.5 mg $3,895/4x0.5 mg $4,450/5x0.5 mg

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Application Data (Biological Acitivity: Human IL-6 stimulates cell proliferation of the TF-1 human erythroleukemic cells. The ED50 range )

SDS-PAGE

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Interleukin 6, Active Protein (Cat# AAA48546)

Full Name

Interleukin 6, 30-212aa, Human, His tag, E Coli (Bioactivity Validated)

Gene Names

IL6; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2

Applications

Bioactivity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$215/0.01 mg $250/0.02 mg $325/0.05 mg $440/0.1 mg $680/0.25 mg $680/5x0.01 mg $860/5x0.02 mg $1,060/0.5 mg $1,140/5x0.05 mg $1,690/5x0.1 mg $2,055/2x0.5 mg $2,770/5x0.25 mg $3,000/3x0.5 mg $3,895/4x0.5 mg $4,450/5x0.5 mg

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Bioactivity (Human CD47 is coated at 1 ug/ml (100 ul/well) can bind Human SIRP gamma/CD172g (CAT# ATGP4030) in a Functional ELISA assay.)

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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CD47, Active Protein (Cat# AAA48392)

Full Name

Recombinant human CD47 protein

Gene Names

CD47; IAP; OA3; MER6

Applications

Bioactivity, SDS-PAGE

Purity

>95% by SDS-PAGE

Pricing

$300/0.01 mg $395/0.02 mg $485/0.05 mg $720/0.1 mg $1,015/5x0.01 mg $1,150/0.25 mg $1,470/5x0.02 mg $1,880/0.5 mg $1,910/5x0.05 mg $2,945/5x0.1 mg $3,660/2x0.5 mg $4,875/5x0.25 mg $5,340/3x0.5 mg $6,935/4x0.5 mg $8,155/5x0.5 mg

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Bioactivity (Mouse IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range )

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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IL-21, Active Protein (Cat# AAA48409)

Full Name

Recombinant Mouse IL-21 Protein

Gene Names

Il21; IL-21

Applications

Bioactivity, SDS-PAGE

Purity

>90% by SDS-PAGE

Pricing

$295/0.01 mg $385/0.02 mg $535/0.05 mg $785/0.1 mg $995/5x0.01 mg $1,275/0.25 mg $1,425/5x0.02 mg $2,075/5x0.05 mg $2,105/0.5 mg $3,240/5x0.1 mg $4,095/2x0.5 mg $5,460/5x0.25 mg $5,980/3x0.5 mg $7,760/4x0.5 mg $9,150/5x0.5 mg

SDS-PAGE

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NME2, Active Protein (Cat# AAA48916)

Full Name

NME2, 1-152aa, Human, E Coli (Bioactivity Validated)

Gene Names

NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2

Applications

Enzyme Activity, SDS-PAGE

Purity

> 90% by SDS-PAGE

Pricing

$185/0.004 mg $250/0.02 mg $440/0.1 mg $550/5x0.004 mg $860/2x0.1 mg $860/5x0.02 mg $1,250/3x0.1 mg $1,625/4x0.1 mg $1,690/5x0.1 mg

SDS-PAGE

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SurA, Active Protein (Cat# AAA48603)

Full Name

SurA, 21-428aa, E Coli, His tag, E Coli (Bioactivity Validated)

Gene Names

surA; ECK0054; JW0052

Applications

SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$235/0.02 mg $375/0.1 mg $780/5x0.02 mg $825/0.5 mg $1,380/5x0.1 mg $1,600/2x0.5 mg $2,335/3x0.5 mg $3,025/4x0.5 mg $3,410/5x0.5 mg

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

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LDHB, Active Protein (Cat# AAA48607)

Full Name

LDHB, 1-334aa, Human, His tag, E Coli (Bioactivity Validated)

Gene Names

LDHB; LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281

Applications

Enzyme Activity, SDS-PAGE

Purity

> 95% by SDS-PAGE

Pricing

$225/0.02 mg $350/0.1 mg $720/5x0.02 mg $730/0.5 mg $1,255/5x0.1 mg $1,425/2x0.5 mg $2,080/3x0.5 mg $2,700/4x0.5 mg $3,005/5x0.5 mg

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Bioactivity (Human IL-6 R alpha inhibits Human IL-6 induced cell proliferation in the M1 mouse myeloid leukemia cells. The ED50 range 20 ng/ml.)

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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IL-6R alpha, Active Protein (Cat# AAA48327)

Full Name

Recombinant IL-6R alpha

Gene Names

IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1

Applications

Bioactivity, SDS-PAGE

Purity

> 90% by SDS - PAGE

Pricing

$290/0.01 mg $380/0.02 mg $520/0.05 mg $775/0.1 mg $990/5x0.01 mg $1,255/0.25 mg $1,410/5x0.02 mg $2,040/5x0.05 mg $2,450/2x0.25 mg $3,185/5x0.1 mg $3,580/3x0.25 mg $4,645/4x0.25 mg $5,355/5x0.25 mg

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Bioactivity (Canine IL-1B stimulates cell proliferation of the D10.G4.1 mouse helper T cells. The ED50 range range )

SDS-PAGE (3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.)

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IL-1 beta/IL-1F2, Active Protein (Cat# AAA48366)

Full Name

Recombinant canine IL-1 beta/IL-1F2 protein

Gene Names

IL1B; IL-1

Applications

Bioactivity, SDS-PAGE

Purity

>95% by SDS-PAGE

Pricing

$310/0.01 mg $400/0.02 mg $580/0.05 mg $875/0.1 mg $1,085/5x0.01 mg $1,410/0.25 mg $1,500/5x0.02 mg $2,305/5x0.05 mg $2,330/0.5 mg $3,620/5x0.1 mg $4,540/2x0.5 mg $6,050/5x0.25 mg $6,630/3x0.5 mg $8,605/4x0.5 mg $10,180/5x0.5 mg

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Application Data (KRAS G12V (HLA-A*03:01) Tetramer SPRSPR image shows curve for KRAS G12V(HLA-A*03:01) and immobilized Antibody binding, with a calculated affinity constant of 42nM)

ELISA (KRAS G12V (HLA-A*03:01) Tetramer ELISADose response curve for Anti-KRAS G12V(HLA-A*03:01) Antibody)

Application Data (KRAS G12V (HLA-A*03:01) Tetramer HPLCThe purity of KRAS G12V (HLA-A*03:01)complex tetramer was greater than 95% as determined by SEC-HPLC.)

SDS-PAGE (KRAS G12V (HLA-A*03:01)Tetramer protein PAGE1ug loaded Tris-Bis PAGE under reducing condition. The purity is greater than 95%.)

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HLA-A*03:01 KRAS G12V, Active Protein (Cat# AAA76371)

Full Name

HLA-A*03:01 KRAS G12V peptide Tetramer

Purity

purity was determined to be >95% by nonreducing PAGE and HPLC

Pricing

$710/0.05 mg $2,360/0.25 mg $4,590/2x0.25 mg $6,705/3x0.25 mg $8,705/4x0.25 mg $10,235/5x0.25 mg

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Application Data (Polarized membrane extensions mediate osteoclast fusion.(D, top) Immunoblot analysis of lysates of RAW264.7 macrophages stimulated with RANKL for the indicated times with antibodies to Ser473-phosphorylated (p) or total forms of Akt.)

Application Data (Expression of pro-resorptive cytokines in gouty tophus tissues.(c) Immunofluorescent stains for CD3 (green) and RANKL (red) in tophaceous gout tissues.)

Application Data (PLC?2 is required for in vitro osteoclast development.(a) Representative TRAP-stained images of wild-type and PLC?2?/? bone marrow cells cultured in the presence of the indicated concentrations of recombinant murine M-CSF and RANKL for 4 days.)

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Soluble RANK ligand, Active Protein (Cat# AAA76384)

Full Name

Mouse Soluble RANK ligand Recombinant

Gene Names

Tnfsf11; ODF; OPG; OPGL; RANKL; Ly109l; Trance

Purity

>95%, as determined by SDS-PAGE and HPLC

Pricing

$245/1 mg $345/0.01 mg $665/2x0.01 mg $965/3x0.01 mg $1,255/4x0.01 mg $23,080/5x1 mg

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Application Data (Generation of conditional TAK1-deficient mice.Colony formation by BM cells from Map3k7)

Application Data (G-CSF production by various mouse tumor models.Sera G-CSF levels determined from nontumor-bearing mice (n?=?10), mice treated with recombinant G-CSF protein (10 ug daily for 5 consecutive days) (n?=?8) or mice bearing 4T1 cells (n?=?9) or AT-3 tumor cells pooled from two separate experiments (n?=?9; overall tumor volume ?2cm3).)

Application Data (Inhibition of neutrophil differentiation by IRF4.Wright-Giemsa staining of 32Dcl.3 cells transduced with empty MSCV-puro, MSCV-IRF4DYKDDDDK-puro or MSCV-IRF8DYKDDDDK-puro and cultured in the presence of IL-3 (upper panels) or G-CSF (for 7 days, lower panels).)

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Granulocyte Colony Stimulating Factor, Active Protein (Cat# AAA76390)

Full Name

Mouse Granulocyte Colony Stimulating Factor Recombinant

Gene Names

Csf3; Csfg; G-CSF; MGI-IG

Purity

>95%, as determined by SDS-PAGE and HPLC

Pricing

$245/0.002 mg $345/0.01 mg $5,225/1 mg $10,175/2x1 mg $14,875/3x1 mg $19,310/4x1 mg $23,080/5x1 mg

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Application Data (Expression of programmed death-1 (PD-1) in macrophages/microglia after spinal cord injury (SCI) in mice.Immunohistochemistry in macrophages/microglia 14 days postinjury (dpi) in wild-type mice for (c) PD-1, (d) it’s ligand, PD-L1, and (e) PD-1 in M1 cells [inducible nitric oxide synthase (iNOS)+]; (f) PD-1 in M2 cells [arginase 1 (Arg1+)]; (g) PD-L1 in M1 cells (iNOS+); and (h) PD-L1 in M2 cells (Arg1+).)

Application Data (MPLA-tDCs exhibit a semi-mature surface phenotype and differentially express high levels of TLR-2.TLR-2, PD-L1, GILZ and ILT3 expression on each DC condition was analyzed by flow cytometry to seek for specific tolerogenic DC markers.)

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PD-L1 (B7-H1), Active Protein (Cat# AAA76402)

Full Name

Human PD-L1 (B7-H1) Recombinant

Gene Names

Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

Purity

>95%, as determined by SDS-PAGE and HPLC

Pricing

$345/0.02 mg $680/0.1 mg $2,275/0.5 mg $4,440/2x0.5 mg $6,485/3x0.5 mg $8,415/4x0.5 mg $9,865/5x0.5 mg

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Application Data

Application Data

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VEGF-E, Heparin-binding, Active Protein (Cat# AAA79120)

Full Name

Orf Virus VEGF-E, Heparin-binding

Reactivity

Orf virus

Purity

> 90% by SDS-PAGE & silver stain

Pricing

$525/0.02 mg $1,015/2x0.02 mg $1,485/3x0.02 mg $1,930/4x0.02 mg $2,020/5x0.02 mg

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Application Data

Application Data

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LIF, Active Protein (Cat# AAA79124)

Full Name

Human LIF

Gene Names

LIF; CDF; DIA; HILDA; MLPLI

Reactivity

Human

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$345/0.01 mg $665/2x0.01 mg $965/3x0.01 mg $1,195/5x0.01 mg $1,255/4x0.01 mg

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Application Data

Application Data

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IL-2, Active Protein (Cat# AAA79197)

Full Name

Human IL-2

Gene Names

IL2; IL-2; TCGF; lymphokine

Reactivity

Human

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$435/0.05 mg $850/2x0.05 mg $1,235/3x0.05 mg $1,605/4x0.05 mg $1,620/5x0.05 mg

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Application Data

Application Data

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PDGF-AA, Active Protein (Cat# AAA79228)

Full Name

Human PDGF-AA

Gene Names

PDGFA; PDGF1; PDGF-A

Reactivity

Human

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$305/0.005 mg $585/2x0.005 mg $850/3x0.005 mg $1,010/5x0.005 mg $1,105/4x0.005 mg

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Application Data

Application Data

Application Data

Application Data

SDS-PAGE

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VEGF-F (Bothrops insularis), Active Protein (Cat# AAA79229)

Full Name

Snake VEGF-F (Bothrops insularis)

Reactivity

Snake

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$435/0.005 mg $850/2x0.005 mg $1,235/3x0.005 mg $1,605/4x0.005 mg $1,620/5x0.005 mg

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Application Data

Application Data

Application Data

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VEGF144, Active Protein (Cat# AAA79241)

Full Name

Mouse VEGF144

Gene Names

Vegfa; Vpf; Vegf

Reactivity

Mouse

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$305/0.002 mg $585/2x0.002 mg $850/3x0.002 mg $1,010/5x0.002 mg $1,105/4x0.002 mg

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Application Data

Application Data

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VEGF121, Active Protein (Cat# AAA79263)

Full Name

Human VEGF121

Gene Names

VEGFA; VPF; VEGF; MVCD1

Reactivity

Human

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$500/0.02 mg $975/2x0.02 mg $1,430/3x0.02 mg $1,855/4x0.02 mg $1,920/5x0.02 mg

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Application Data

Application Data

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VEGF121, Active Protein (Cat# AAA79264)

Full Name

Human VEGF121

Gene Names

VEGFA; VPF; VEGF; MVCD1

Reactivity

Human

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$345/0.005 mg $665/2x0.005 mg $965/3x0.005 mg $1,195/5x0.005 mg $1,255/4x0.005 mg

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Application Data

Application Data

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VEGF164, Active Protein (Cat# AAA79269)

Full Name

Mouse VEGF164

Gene Names

Vegfa; Vpf; Vegf

Reactivity

Mouse

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$305/0.002 mg $585/2x0.002 mg $850/3x0.002 mg $1,010/5x0.002 mg $1,105/4x0.002 mg

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Application Data (In vitro: The proliferative response to recombinant rat VEGF-CC152S was assayed in VEGFR3-expressing porcine aortic endothelial (PAE) cells. Briefly, cells were plated in 12-well plates and incubated in DMEM medium supplemented with 1% fetal calf serum for cell cycle arrest 24h prior to stimulation of cell proliferation with recombinant VEGF-CC152S at the concentrations of 50 and 100 ng/mL. After 48h in culture, the cell proliferative response was assayed (WST-1 colorimetric assay), and the results expressed as % of control non-stimulated cells (mean + sem).)

Application Data (In vivo: The lymphangiogenic response to recombinant rat VEGFCC152S loaded in our biopolymeric albumin-alginate microcapsules for targeted slow-release was assayed in male Wistar rats. Briefly, after ischemiareperfusion injury to induce myocardial infarction, VEGF-CC152S at the dose of 1.5 or 5 ug per heart was injected intra-myocardially. Lymphatic responses in the myocardium were analyzed by IHC at 3 weeks post-MI using LYVE1 antibody. Results are expressed as lymphatic vessel to cardiomyocyte ratio (mean + sem).The experiments were performed by the research group of Prof. Dr. E. Brakenhielm – Rouen University (see also: Henri O et al., Circulation, March 2016, DOI: 10.1161))

SDS-PAGE (SDS-PAGE analysis of recombinant rat VEGF-C152 mutant. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.)

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VEGF-C152S, Active Protein (Cat# AAA79274)

Full Name

Rat VEGF-C152S

Reactivity

Rat

Purity

> 90% by SDS-PAGE & silver stain

Pricing

$305/0.005 mg $585/2x0.005 mg $850/3x0.005 mg $1,010/5x0.005 mg $1,105/4x0.005 mg

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Application Data

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FGF-4, Active Protein (Cat# AAA79291)

Full Name

Human FGF-4

Gene Names

FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4

Reactivity

Human

Purity

> 95% by SDS-PAGE & silver stain

Pricing

$435/0.025 mg $850/2x0.025 mg $1,235/3x0.025 mg $1,605/4x0.025 mg $1,620/5x0.025 mg

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Application Data

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SCF, Active Protein (Cat# AAA79295)

Full Name

Human SCF

Gene Names

KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7

Reactivity

Human

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$345/0.01 mg $665/2x0.01 mg $965/3x0.01 mg $1,195/5x0.01 mg $1,255/4x0.01 mg

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Application Data

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FGF-2 (basic), Active Protein (Cat# AAA79309)

Full Name

Rat FGF-2 (basic)

Gene Names

Fgf2; bFGF; Fgf-2

Reactivity

Rat

Purity

> 98% by SDS-PAGE & silver stain

Pricing

$525/0.05 mg $1,015/2x0.05 mg $1,485/3x0.05 mg $1,930/4x0.05 mg $2,020/5x0.05 mg

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Application Data (Binding of recombinant human Wnt5a to recombinant human sROR2 in a functional ELISA. sROR2 was coated with 2ug/ml (100ug/well) and increasing amounts of Wnt5a was added. Detection was performed using a polyclonal rabbit anti-human Wnt5a and a goat anti-rabbit Biotin conjugated secondary antibody.)

SDS-PAGE (SDS-PAGE analysis of recombinant human sROR2 produced in insect cells. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.)

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ROR2, Active Protein (Cat# AAA79320)

Full Name

Human ROR2, soluble

Gene Names

ROR2; BDB; BDB1; NTRKR2

Reactivity

Human

Purity

> 98% by SDS-PAGE & Coomassie stain

Pricing

$345/0.002 mg $525/0.01 mg $1,015/2x0.01 mg $1,485/3x0.01 mg $1,930/4x0.01 mg $2,020/5x0.01 mg

What Are Active Proteins?

Proteins are large molecules made up of long chains of amino acids.
They will typically fold into a very particular 3-dimensional shape/conformation, that is sometimes referred to as their “native” form, which allows them to work properly in the body. For the purposes of product categorization, AAA Biotech will typically refer to proteins purified from their original animal host as being “native” proteins (this is to signify their difference compared to their “recombinant” or “synthetic” protein counterparts).

If a protein successfully folds into the correct shape, it is will typically display high fidelity characteristics to its original protein in its original animal host, and be classified as an active protein, as it will be able to function “normally” in most enzymatic or binding capacities. If it loses this shape, due to factors such as heat or strong chemicals (such as detergents), it becomes inactive and is no longer able to perform its basic functions. All of the proteins in this category are made under strict quality control, and they are active, pure, low in contaminants, and stable.
Most are stored as freeze-dried powders and come without extra tags, so they’re very close to the actual natural/native form.

Key Applications of Active Proteins

1. Scientific Research

• Aid in the study of how proteins function in the body


• Aid in understanding various disease processes

2. Drug Development

• Powerful tools to investigate how potential drugs interact with specific proteins


• Ideal for identifying drug targets

3. Cell Culture

• Are routinely utilized to support cell growth and function (e.g., using exogenous growth factors)


• Can be used to promote cellular development into specific types (differentiation)

4. Diagnostics

• Regularly utilized in tests to detect diseases or infections (e.g., COVID-19, cancer)


• Note: All products are strictly for research-use only (RUO).

5. Therapeutics

• Some active proteins are used directly as treatments (e.g., insulin, enzymes)


• Note: All products are strictly for research-use only (RUO).

6. Vaccine Development

• Used to create or test vaccines by mimicking parts of viruses or bacteria

7. Biochemical Assays

• They can facilitate the characterization of enzyme activity, binding strength, or protein interactions in lab tests

Why Buy Active Proteins from AAA Biotech?

• High biological activity – Verified to perform as expected or indicated on datasheet


• Strict quality control – We are confident in our active proteins’ reliability and consistency


• High purity & low endotoxin – Ideal for applications involving sensitive or precious samples/components


• Freeze-dried for stability – Long shelf life and straightforward storage


• Mostly tag-free – Closer to natural/native protein form

FAQ

1. What are active proteins used for in research?

Active proteins are used primarily in the study of how proteins function, in characterizing/discovering drug interactions, supporting cell growth, running biochemical assays, and in development of diagnostics or therapeutics.

2. How are AAA Biotech's active proteins validated?

AAA Biotech’s active proteins are validated through strict quality control and functional assays to ensure they are properly folded and active. “Active”, though, can be an ambiguous term, so if a specific “activity” or “binding” capability of a protein is of crucial interest to you, please inquire with us prior to purchase, and we will provide further details on how the “Active” modifier was determined to be applicable.

3. Are these proteins tested for biological activity?

Yes, all active proteins from AAA Biotech are tested to confirm they have the expected biological activity before being offered for use. Though, said “biological activity” can be either “enzymatic”, “binding”, or both.