Recombinant Antibodies

What are recombinant antibodies?

Recombinant antibodies are produced in the lab by utilizing a known genetic sequence (an amino acid and nucleotide sequence). This allows for high consistency in how each new lot will perform and how specific they will be for the target, regardless of how many times they are produced/reproduced.

They help solve the problems observed when traditional non-recombinant techniques are utilized, such as changes in cell behavior over time, differences between production batches, and accuracy in complex biological systems.

A powerful feature of recombinant antibodies is that they can also be modified through progressive genetic engineering and subsequent testing in order to make them perform better and/or more reliably.

Applications For Recombinant Antibodies

1. Basic Research

Recombinant antibodies are primarily utilized in laboratory experiments to study the function of various proteins in cells. They are helpful in finding and tracking specific molecules through their use in techniques such as ELISA, Western blotting, immunofluorescence, and flow cytometry.

2. Diagnostics

They are also key components in diagnostic tests used to detect diseases and infections. As recombinant antibodies are produced in a consistent and controlled way, they are able to provide highly reliable results across batches. Though recombinant antibodies are indeed quite useful in diagnostic applications, all of the products listed in AAA Biotech’s also known as AAA Bio or AAABio catalog are strictly for research-use only (RUO).

3. Therapeutics (Medical Treatments)

Please note that all of the products listed in AAA Biotech’s catalog are strictly for research-use only (RUO).

• Chimeric Antibodies: Commonly used in therapeutic treatment. They combine different pieces of mouse and human antibodies in order to reduce immune reactions.


• Humanized Antibodies: Modified non-human antibodies that are made to look the same as actual native human antibodies, making them safer and more effective.


• Antibody Fragments (Fab, scFv, VHH): Smaller pieces of antibody fragments that can reach deep into tissues and tumors. They are useful in cancer treatments and imaging.


• Bispecific Antibodies: Specially-engineered antibodies that can bind to two different target molecules at once. Each antibody has two “arms” that allow for two places where the target antigen can bind (both “arms” will recognize the same exact epitope). These bispecific antibodies are engineered so that each arm can detect a completely different epitope than the other. Used in many of the treatments for cancer, diabetes, Alzheimer’s disease, and more.


• Fc-Fusion Proteins: Used as drugs and research tools. They combine parts of antibodies with other proteins to improve stability and effectiveness.

4. Imaging and Detection

Small antibody fragments are also used as imaging agents in medical scans. Their small size helps them reach and report on the status of tumors quickly.

5. Drug Development and Delivery

Recombinant antibodies can also be designed and made to deliver drugs directly to diseased cells, especially in targeted cancer therapy.

6. Immunotherapy

These antibodies can aid the immune system recognize and fight diseases more effectively, which is often their role in cancer treatment.

Please note that all of the products listed in AAA Biotech’s catalog are strictly for research-use only (RUO).

Advantages of Recombinant Antibodies

• Reliable Results Every Time: Recombinant antibodies are exceptionally consistent from batch to batch. This means researchers can trust that results will remain the same each time they purchase and use them.


• More Specific and Accurate: Compared to polyclonal antibodies, recombinant antibodies are significantly less likely to exhibit non-specific binding, which promotes more accurate and clearer results.


• Easier to Develop: Making recombinant antibodies is simpler and quicker than the traditional method of producing monoclonal antibodies via hybridomas.


• No Genetic Drift: Over time, hybridoma cells can change or become unstable, which can result in the antibodies progressively losing their function/specificity. Recombinant antibodies avoid this problem because they are produced from a fixed template DNA sequence.


• Truly Monoclonal: Studies have shown that many hybridomas thought to be monoclonal actually are not so, which can lead to, in some cases, unreliable results. Recombinant antibodies are made using precise genetic sequence templates, ensuring they are truly specific to one target.


• Long-Term Stability and Safety: Since their amino acid and genetic sequences are known and stored, recombinant antibodies can be reproduced at any time with the same quality. This method protects against contamination, genetic changes over time, or even accidental loss/deterioration of cell lines.

Why Buy Recombinant Antibody from AAA Biotech?

• Highly Validated: The vast majority of our antibodies are thoroughly tested to ensure they work reliably across different applications and experimental platforms.


• Versatile Applications: Our antibodies can be used in a wide range of research techniques, including (but not limited to) immunocytochemistry (ICC), ELISA, immunofluorescence (IF), immunohistochemistry (IHC), flow cytometry (FC), immunoprecipitation (IP), and Western blotting (WB).


• Support for Rare Species: We offer antibodies specifically designed for rare or less commonly used laboratory species — something many other suppliers do not provide.


• Wide Selection of Conjugated and Recombinant Forms: Choose from various labeled (conjugated) options and browse our high-quality recombinant antibodies – we are confident that we will have materials to meet your research needs.

Please note that all of the products listed in AAA Biotech’s catalog are strictly for research-use only (RUO).

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