IHC (Immunohiostchemistry)
(TRPM8 Antibody-Anti-TRPM8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Rabbit anti-Human TRPM8 Polyclonal Antibody | anti-TRPM8 antibody
TRPM8 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Gene Names
TRPM8; TRPP8; LTRPC6
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
TRPM8, Antibody; TRPM8 Rabbit anti-Human Polyclonal (aa251-300) Antibody; PathPlus TRPM8 Antibody (aa251-300); TRPM8; CMR1; Cold-menthol receptor type 1; LTrpC-6; TRPP8; Trp-p8; LTRPC6; anti-TRPM8 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human TRPM8
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.09% sodium azide, 2% sucrose
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-TRPM8 antibody
WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human TRPM8
Immunogen
Synthetic peptide located between aa251-300 of human TRPM8 (Q7Z2W7, NP_076985). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset, Panda, Dog, Bat, Rabbit, Horse, Pig, Armadillo (100%); Mouse, Rat, Elephant, Opossum, Platypus (92%); Galago, Guinea pig (85%).
Conjugation
Unconjugated
Epitope
aa251-300
Family
Ion Channel
Subfamily
Calcium channel-TRP
Preparation and Storage
Short term: Store at 2-8 degree C. Long term: Aliquot and store at -20 degree C. Avoid freeze/thaw cycles.
IHC (Immunohiostchemistry)
(TRPM8 Antibody-Anti-TRPM8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
IHC (Immunohiostchemistry)
(TRPM8 Antibody-Anti-TRPM8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(TRPM8 Antibody-TRPM8 antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(TRPM8 Antibody-TRPM8 antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Related Product Information for anti-TRPM8 antibody
TRPM8 antibody is an unconjugated rabbit polyclonal antibody to TRPM8 (aa251-300) from human. It is reactive with human, bat, dog and other species. Validated for IHC and WB.
TRPM8 is a transmembrane ion channel protein that is activated by cooling and is involved in menthol and cold sensation. Loss of TRPM8 in mice results in changes in response behaviors to cold temperatures such as decreased cold avoidance. In prostate cancer cells, TRPM8 is highly expressed and is involved in cancer cell growth, survival and regulation of calcium levels in androgen-dependent cancers, making it a potential target of therapy. In immunohistochemistry of normal tissue, it has plasma membrane positivity in the prostate and liver, with localization in the endoplasmic reticulum in prostate cancer cells.
TRPM8 is a transmembrane ion channel protein that is activated by cooling and is involved in menthol and cold sensation. Loss of TRPM8 in mice results in changes in response behaviors to cold temperatures such as decreased cold avoidance. In prostate cancer cells, TRPM8 is highly expressed and is involved in cancer cell growth, survival and regulation of calcium levels in androgen-dependent cancers, making it a potential target of therapy. In immunohistochemistry of normal tissue, it has plasma membrane positivity in the prostate and liver, with localization in the endoplasmic reticulum in prostate cancer cells.
References
CRC Press/Taylor & Francis; 2007. Chapter 13. Frontiers in Neuroscience. PMID: 21204488; Neuron. 2007 May 3;54(3):371-8; Cancer Res. 2004 Nov 15;64(22):8365-73, PMID: 15548706; The UniProt Consortium. Nucleic Acids Research. 2019. 47 (D1): D506 -D515, DOI: 10.1093/nar/gky1049;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
79,096 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 8
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 8
NCBI Official Symbol
TRPM8
NCBI Official Synonym Symbols
TRPP8; LTRPC6
NCBI Protein Information
transient receptor potential cation channel subfamily M member 8
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 8
UniProt Gene Name
TRPM8
UniProt Synonym Gene Names
LTRPC6; TRPP8; LTrpC-6; LTrpC6; Trp-p8
UniProt Entry Name
TRPM8_HUMAN
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Product Notes
The TRPM8 trpm8 (Catalog #AAA162558) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPM8 Rabbit anti-Human Polyclonal (aa251-300) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRPM8 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TRPM8 trpm8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPM8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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