IF (Immunofluorescence)
(Immunofluorescence of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 20 μg/ml.)
Rabbit SESTRIN2 Polyclonal Antibody | anti-SESN2 antibody
SESTRIN2 Antibody
Gene Names
SESN2; HI95; SES2; SEST2
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
Purity
SESTRIN2 antibody is affinity chromatography purified via peptide column.
Synonyms
SESTRIN2, Antibody; SESTRIN2 Antibody; SESTRIN-2; SES2; SEST2; SESN2; HI95; sestrin 2; anti-SESN2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist; this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.
Purity/Purification
SESTRIN2 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
480
Applicable Applications for anti-SESN2 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2.
Buffer
SESTRIN2 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SESTRIN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
IF (Immunofluorescence)
(Immunofluorescence of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 20 μg/ml.)
IF (Immunofluorescence)
(Immunofluorescence of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 20 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 5 μg/ml.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 5 μg/ml.)
WB (Western Blot)
(Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)
Related Product Information for anti-SESN2 antibody
SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2). SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 54 kDa
Observed: 53 kDa
Observed: 53 kDa
NCBI Official Full Name
sestrin-2
NCBI Official Synonym Full Names
sestrin 2
NCBI Official Symbol
SESN2
NCBI Official Synonym Symbols
HI95; SES2; SEST2
NCBI Protein Information
sestrin-2; hypoxia induced gene 95
UniProt Protein Name
Sestrin-2
UniProt Gene Name
SESN2
UniProt Synonym Gene Names
SEST2
UniProt Entry Name
SESN2_HUMAN
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Product Notes
The SESN2 sesn2 (Catalog #AAA40556) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SESTRIN2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SESTRIN2 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SESN2 sesn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SESTRIN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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