IHC (Immunohistochemisry)
(SERPINA1/Alpha 1 Antitrypsin Antibody-Humam Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human SERPINA1/Alpha 1 Antitrypsin Polyclonal Antibody | anti-SERPINA1 antibody
SERPINA1/Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Gene Names
SERPINA1; PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Protein A purified
Synonyms
SERPINA1/Alpha 1 Antitrypsin, Antibody; SERPINA1/Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (C-Terminus) Antibody; PathPlus SERPINA1/Alpha 1 Antitrypsin Antibody (C-Terminus); SERPINA1; A1A; A1AT; AAT; Alpha 1 Antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha1AT; PRO2275; Alpha-1-antitrypsin null; PI1; Serpin A1; Alpha 1 AT; anti-SERPINA1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human SERPINA1/Alpha-1-Antitrypsin
Purity/Purification
Protein A purified
Form/Format
PBS, 0.09% sodium azide, 2% sucrose
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SERPINA1 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human SERPINA1/Alpha 1 Antitrypsin
Immunogen
Synthetic peptide from C-Terminus of human SERPINA1 (P01009, NP_000286). Percent identity by BLAST analysis: Human (100%).
Conjugation
Unconjugated
Epitope
C-Terminus
Preparation and Storage
Short term: Store at 2-8 degree C. Long term: Aliquot and store at -20 degree C. Avoid freeze/thaw cycles.
IHC (Immunohistochemisry)
(SERPINA1/Alpha 1 Antitrypsin Antibody-Humam Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(SERPINA1/Alpha 1 Antitrypsin Antibody-Humam Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(SERPINA1/Alpha 1 Antitrypsin Antibody-Humam Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(SERPINA1/Alpha 1 Antitrypsin Antibody-Humam Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(SERPINA1/Alpha 1 Antitrypsin Antibody-HepG2 Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(SERPINA1/Alpha 1 Antitrypsin Antibody-HepG2 Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Related Product Information for anti-SERPINA1 antibody
Alpha 1 Antitrypsin antibody is an unconjugated rabbit polyclonal antibody to human Alpha 1 Antitrypsin (SERPINA1)(C-Terminus). Validated for IHC and WB.
SERPINA1 (also known as Alpha 1 Antitrypsin) is an inhibitor of serine proteases that primarily targets elastase but also has a moderate affinity for plasmin and thrombin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). The aberrant form of SERPINA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. SERPINA1 is a secreted protein, and in immunohistochemistry it has plasma and extracellular matrix positivity in most tissues throughout the body.
SERPINA1 (also known as Alpha 1 Antitrypsin) is an inhibitor of serine proteases that primarily targets elastase but also has a moderate affinity for plasmin and thrombin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). The aberrant form of SERPINA1 inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. SERPINA1 is a secreted protein, and in immunohistochemistry it has plasma and extracellular matrix positivity in most tissues throughout the body.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
46,737 Da
NCBI Official Full Name
alpha-1-antitrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
NCBI Official Symbol
SERPINA1
NCBI Official Synonym Symbols
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
NCBI Protein Information
alpha-1-antitrypsin; serpin A1; alpha-1-antiproteinase; alpha-1-antitrypsin null; alpha-1 protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1
UniProt Protein Name
Alpha-1-antitrypsin
UniProt Gene Name
SERPINA1
UniProt Synonym Gene Names
AAT; PI; SPAAT
UniProt Entry Name
A1AT_HUMAN
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Product Notes
The SERPINA1 serpina1 (Catalog #AAA163103) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SERPINA1/Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (C-Terminus) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SERPINA1/Alpha 1 Antitrypsin can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the SERPINA1 serpina1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SERPINA1/Alpha 1 Antitrypsin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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