Application Data
Rabbit Neuropilin-1 (a1 CUB Domain) Polyclonal Antibody | anti-NRP1 antibody
Neuropilin-1 (a1 CUB Domain)
Gene Names
NRP1; NP1; NRP; BDCA4; CD304; VEGF165R; DKFZp781F1414; DKFZp686A03134
Reactivity
Human, Rat, Mouse
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Affinity Purified
Synonyms
Neuropilin-1 (a1 CUB Domain), Antibody; Neuropilin-1 (a1 CUB Domain); NRP1; Vascular endothelial cell growth factor 165 receptor; anti-NRP1 antibody
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Specificity
This antibody detects a 130 kDa* protein corresponding to the apparent molecular mass of neuropilin-1 on SDS-PAGE immunoblots of COS-7 cells transfected with mouse neuropilin-1. In immunocytochemistry, this antibody co-localizes with anti-HA in Cos-7 cells transfected with HA-tagged mouse neuropilin-1.
Purity/Purification
Affinity Purified
Form/Format
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Sequence Length
923
Applicable Applications for anti-NRP1 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen
Neuropilin-1 synthetic peptide (coupled to carrier protein) corresponding to amino acids within the a1 CUB domain of human neuropilin-1. This sequence is highly conserved in rat and mouse neuropilin-1, and has low homology to neuropilin-2.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Application Data
Application Data
Application Data
Application Data
Related Product Information for anti-NRP1 antibody
Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its coreceptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
References
• He, Z. & Tessier-Lavigne, M. (1997) Cell 90:739.
• Nakamura, F. & Goshima, Y. (2002) Adv Exp Med Biol. 515:55.
• Takahashi, T. et al. (1999) Cell 99:59.
• Saban, M.R. et al. (2008) Am J Phys Renal Phys 295(1):F60 (ICC: H. Urothelium)
• Nakamura, F. & Goshima, Y. (2002) Adv Exp Med Biol. 515:55.
• Takahashi, T. et al. (1999) Cell 99:59.
• Saban, M.R. et al. (2008) Am J Phys Renal Phys 295(1):F60 (ICC: H. Urothelium)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
102976 Da
NCBI Official Full Name
neuropilin-1 isoform a
NCBI Official Synonym Full Names
neuropilin 1
NCBI Official Symbol
NRP1
NCBI Official Synonym Symbols
NP1; NRP; BDCA4; CD304; VEGF165R; DKFZp781F1414; DKFZp686A03134
NCBI Protein Information
neuropilin-1; OTTHUMP00000020818; OTTHUMP00000020819; OTTHUMP00000020820; OTTHUMP00000020821; OTTHUMP00000020822; transmembrane receptor; vascular endothelial cell growth factor 165 receptor
UniProt Protein Name
Neuropilin-1
UniProt Gene Name
NRP1
UniProt Synonym Gene Names
NRP; VEGF165R
UniProt Entry Name
NRP1_HUMAN
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Product Notes
The NRP1 nrp1 (Catalog #AAA71524) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Neuropilin-1 (a1 CUB Domain) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Neuropilin-1 (a1 CUB Domain) can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the NRP1 nrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuropilin-1 (a1 CUB Domain), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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