Rabbit MYOG Polyclonal Antibody | anti-MYOG antibody

MYOG Antibody

Cat. Num. AAA327446

• Gene Names: MYOG; MYF4; myf-4; bHLHc3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Peptide affinity purification
• Synonyms: MYOG, Antibody; MYOG Antibody; bHLHc3; cb553; Class C basic helix-loop-helix protein 3; MYF 4; Myf-4; MYF4; MYOG; MYOG_HUMAN; Myogenic factor 4; Myogenic factor 4 myogenin; Myogenin; Myogenin myogenin factor 4; OTTHUMP00000039094; anti-MYOG antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MYOG antibody detects endogenous levels of total MYOG
• Purity/Purification: Peptide affinity purification
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 224

• Applicable Applications for anti-MYOG antibody: ELISA, WB (Western Blot)
• Immunogen: A synthesized peptide derived from human MYOG, corresponding to a region within the C-Terminal amino acids.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

WB (Western Blot)

(Western blot analysis of MYOG using HeLa whole cell lysates)

Related Product Information for anti-MYOG antibody

Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).
Subunit Structure: Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex (By similarity). Interacts with CSRP3.
Post-translational Modifications: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 18765727
• NCBI GeneID: 4656
• NCBI Accession #: NP_002470.2
• NCBI GenBank Nucleotide #: NM_002479.5
• UniProt Accession #: P15173; Q53XW6
• Molecular Weight: 25kDa
• NCBI Official Full Name: myogenin
• NCBI Official Synonym Full Names: myogenin
• NCBI Official Symbol: MYOG
• NCBI Official Synonym Symbols: MYF4; myf-4; bHLHc3
• NCBI Protein Information: myogenin
• UniProt Protein Name: Myogenin
• UniProt Gene Name: MYOG
• UniProt Synonym Gene Names: BHLHC3; MYF4; bHLHc3; Myf-4