WB (Western Blot)
(Western blot analysis of extracts from JK cells (Lane 2), using MAP3K7 (Ab-187) antiobdy. The lane on the left is treated with synthesized peptide.)
Rabbit anti-Human MAP3K7 Polyclonal Antibody | anti-MAP3K7 antibody
MAP3K7 (Ab-187) Antibody
Gene Names
MAP3K7; TAK1; MEKK7; TGF1a
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
MAP3K7, Antibody; MAP3K7 (Ab-187) Antibody; EC 2.7.11.25; kinase TAK1; M3K7; MAP3K7; Mitogen-activated protein kinase kinase kinase 7; anti-MAP3K7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total MAP3K7 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
579
Applicable Applications for anti-MAP3K7 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized non-phosphopeptide derived from human MAP3K7 around the phosphorylation site of threonine 187 (H-M-T(p)-N-N).
Target Name
MAP3K7
Preparation and Storage
Store at -20 degree C
WB (Western Blot)
(Western blot analysis of extracts from JK cells (Lane 2), using MAP3K7 (Ab-187) antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from JK cells (Lane 2), using MAP3K7 (Ab-187) antiobdy. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Jurkat cells, treated with heat shock, using MAP3K7 (Ab-187) antibody.)
WB (Western Blot)
(Western blot analysis of extracts from Jurkat cells, treated with heat shock, using MAP3K7 (Ab-187) antibody.)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MAP3K7 (Ab-187) antibody.)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MAP3K7 (Ab-187) antibody.)
Related Product Information for anti-MAP3K7 antibody
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.Sakurai H., Biochem. Biophys. Res. Commun. 243:545-549(1998).Mungall A.J., Nature 425:805-811(2003).The MGC Project Team; Genome Res. 14:2121-2127(2004).
Product Categories/Family for anti-MAP3K7 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,740 Da
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase 7 isoform A
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 7
NCBI Official Symbol
MAP3K7
NCBI Official Synonym Symbols
TAK1; MEKK7; TGF1a
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 7
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 7
UniProt Gene Name
MAP3K7
UniProt Synonym Gene Names
TAK1; TGF-beta-activated kinase 1
UniProt Entry Name
M3K7_HUMAN
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Product Notes
The MAP3K7 map3k7 (Catalog #AAA305976) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAP3K7 (Ab-187) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MAP3K7 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the MAP3K7 map3k7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAP3K7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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