Rabbit anti-Human, Mouse JAB1 Polyclonal Antibody | anti-JAB1 antibody

JAB1 Polyclonal Antibody

Cat. Num. AAA295102

• Gene Names: COPS5; CSN5; JAB1; SGN5; MOV-34
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Synonyms: JAB1, Antibody; JAB1 Polyclonal Antibody; COPS5; CSN5; JAB1; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein 1; anti-JAB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal

• Applicable Applications for anti-JAB1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

IHC (Immunohistochemistry)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.)

IHC (Immunohistochemisry)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.)

Related Product Information for anti-JAB1 antibody

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

NCBI and Uniprot Product Information

• NCBI GI #: 38027923
• NCBI GeneID: 10987
• NCBI Accession #: NP_006828.2
• NCBI GenBank Nucleotide #: NM_006837.2
• UniProt Accession #: Q92905; O15386; Q6AW95; Q86WQ4; Q9BQ17
• Molecular Weight: 37,579 Da
• NCBI Official Full Name: COP9 signalosome complex subunit 5
• NCBI Official Synonym Full Names: COP9 signalosome subunit 5
• NCBI Official Symbol: COPS5
• NCBI Official Synonym Symbols: CSN5; JAB1; SGN5; MOV-34
• NCBI Protein Information: COP9 signalosome complex subunit 5; 38 kDa Mov34 homolog; signalosome subunit 5; jun activation domain-binding protein 1; COP9 constitutive photomorphogenic homolog subunit 5
• UniProt Protein Name: COP9 signalosome complex subunit 5
• UniProt Gene Name: COPS5
• UniProt Synonym Gene Names: CSN5; JAB1; SGN5
• UniProt Entry Name: CSN5_HUMAN