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IHC (Immunohistochemistry)
(IFIH1/MDA5 Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human IFIH1/MDA5 Polyclonal Antibody | anti-IFIH1 antibody
IFIH1/MDA5 Rabbit anti-Human Polyclonal Antibody
Gene Names
IFIH1; Hlcd; MDA5; MDA-5; RLR-2; IDDM19
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
IFIH1/MDA5, Antibody; IFIH1/MDA5 Rabbit anti-Human Polyclonal Antibody; PathPlus IFIH1/MDA5 Antibody; IFIH1; Helicase with 2 CARD domains; MDA-5; MDA5; Helicard; IDDM19; RLR-2; RH116; CADM-140 autoantigen; Hlcd; RIG-I-like receptor 2; anti-IFIH1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-IFIH1 antibody
IHC (Immunohistochemistry)
Target
Human IFIH1/MDA5
Immunogen
LP-10978, synthetic peptide
Conjugation
Unconjugated
Family
DEAD box protein
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemistry)
(IFIH1/MDA5 Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(IFIH1/MDA5 Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(IFIH1/MDA5 Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(IFIH1/MDA5 Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(IFIH1/MDA5 Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(IFIH1/MDA5 Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(IFIH1/MDA5 Antibody-Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(IFIH1/MDA5 Antibody-Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-IFIH1 antibody
MDA5 antibody is an unconjugated rabbit polyclonal antibody to MDA5 (IFIH1) from human. Validated for IHC.
IFIH1 (Interferon-induced helicase C domain-containing protein 1) is an innate immune receptor that acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. It is responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG), and it can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. It is further involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. IFIH1 plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). It may play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. In immunohistochemistry, IFIH1 has cytoplasmic and nuclear positivity in most tissues throughout the body (nuclear localization is thought to occur during apoptosis).
IFIH1 (Interferon-induced helicase C domain-containing protein 1) is an innate immune receptor that acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. It is responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG), and it can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. It is further involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. IFIH1 plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). It may play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. In immunohistochemistry, IFIH1 has cytoplasmic and nuclear positivity in most tissues throughout the body (nuclear localization is thought to occur during apoptosis).
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
interferon-induced helicase C domain-containing protein 1
NCBI Official Synonym Full Names
interferon induced with helicase C domain 1
NCBI Official Symbol
IFIH1
NCBI Official Synonym Symbols
Hlcd; MDA5; MDA-5; RLR-2; IDDM19
NCBI Protein Information
interferon-induced helicase C domain-containing protein 1; helicard; CADM-140 autoantigen; RIG-I-like receptor 2; helicase with 2 CARD domains; RNA helicase-DEAD box protein 116; murabutide down-regulated protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypept
UniProt Protein Name
Interferon-induced helicase C domain-containing protein 1
UniProt Gene Name
IFIH1
UniProt Synonym Gene Names
MDA5; RH116; CADM-140 autoantigen; Helicard; MDA-5; RLR-2
UniProt Entry Name
IFIH1_HUMAN
Similar Products
Product Notes
The IFIH1 ifih1 (Catalog #AAA163015) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IFIH1/MDA5 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IFIH1/MDA5 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the IFIH1 ifih1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFIH1/MDA5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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