IHC (Immunohistochemisry)
(GLUL/Glutamine Synthetase Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human GLUL/Glutamine Synthetase Polyclonal Antibody | anti-GLUL antibody
GLUL/Glutamine Synthetase Rabbit anti-Human Polyclonal Antibody
Gene Names
GLUL; GS; GLNS; PIG43; PIG59
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
GLUL/Glutamine Synthetase, Antibody; GLUL/Glutamine Synthetase Rabbit anti-Human Polyclonal Antibody; PathPlus GLUL/Glutamine Synthetase Antibody; GLUL; GLNS; Glutamate decarboxylase; Glutamate-ammonia ligase; Glutamine synthase; GS; Glutamate--ammonia ligase; Glutamine synthetase; PIG43; PIG59; anti-GLUL antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-GLUL antibody
IHC (Immunohistochemistry)
Target
Human GLUL/Glutamine Synthetase
Immunogen
LP-12731, synthetic peptide
Conjugation
Unconjugated
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemisry)
(GLUL/Glutamine Synthetase Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(GLUL/Glutamine Synthetase Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(GLUL/Glutamine Synthetase Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(GLUL/Glutamine Synthetase Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(GLUL/Glutamine Synthetase Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(GLUL/Glutamine Synthetase Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-GLUL antibody
Glutamine Synthetase antibody is an unconjugated rabbit polyclonal antibody to Glutamine Synthetase (GLUL) from human. Validated for IHC.
GLUL (GS) belongs to the glutamine synthetase family and functions to catalyze the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. GLUL antibodies can be used in a panel with HSP70 and GPC3 antibodies to distinguish hepatocellular carcinoma (at least two out of three positive) from nonmalignant lesions. In immunohistochemistry of normal tissue, GLUL has cytoplasmic positivity in adipocytes, glial cells, macrophages and hepatocytes in multiple tissues, including the brain, thyroid, lung, liver, pancreas, intestine, bladder, breast and reproductive organs.
GLUL (GS) belongs to the glutamine synthetase family and functions to catalyze the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. GLUL antibodies can be used in a panel with HSP70 and GPC3 antibodies to distinguish hepatocellular carcinoma (at least two out of three positive) from nonmalignant lesions. In immunohistochemistry of normal tissue, GLUL has cytoplasmic positivity in adipocytes, glial cells, macrophages and hepatocytes in multiple tissues, including the brain, thyroid, lung, liver, pancreas, intestine, bladder, breast and reproductive organs.
References
Hepatology. 2007 Mar;45(3):725-34, PMID: 17326147; J Hepatol. 2009 Apr;50(4):746-54: 19231003
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42,064 Da
NCBI Official Full Name
glutamine synthetase
NCBI Official Synonym Full Names
glutamate-ammonia ligase
NCBI Official Symbol
GLUL
NCBI Official Synonym Symbols
GS; GLNS; PIG43; PIG59
NCBI Protein Information
glutamine synthetase; glutamine synthase; glutamate decarboxylase; proliferation-inducing protein 43; cell proliferation-inducing protein 59
UniProt Protein Name
Glutamine synthetase
UniProt Gene Name
GLUL
UniProt Synonym Gene Names
GLNS; GS
UniProt Entry Name
GLNA_HUMAN
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Product Notes
The GLUL glul (Catalog #AAA163188) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GLUL/Glutamine Synthetase Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GLUL/Glutamine Synthetase can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the GLUL glul for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GLUL/Glutamine Synthetase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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