IHC (Immunohiostchemistry)
(Anti-CUEDC2 antibody, AAA45375, IHC(P)IHC(P): Human Thyroid Cancer Tissue)
Rabbit CUEDC2 Polyclonal Antibody | anti-CUEDC2 antibody
Anti-CUEDC2 antibody
Gene Names
CUEDC2; C10orf66; bA18I14.5
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
CUEDC2, Antibody; Anti-CUEDC2 antibody; CUE domain-containing protein 2; CUE domain containing 2; bA18I14.5 antibody; C10orf66 antibody; Chromosome 10 open reading frame 66 antibody; CUE domain containing 2 antibody; CUE domain-containing protein 2 antibody; CUED2 antibody; CUED2_HUMAN antibody; Cuedc2 antibody; MGC2491 antibody; OTTHUMP00000020368 antibody; anti-CUEDC2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
287
Applicable Applications for anti-CUEDC2 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CUEDC2 (267-287aa EAEEMKATYINLKPARKYRFH), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohiostchemistry)
(Anti-CUEDC2 antibody, AAA45375, IHC(P)IHC(P): Human Thyroid Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti-CUEDC2 antibody, AAA45375, IHC(P)IHC(P): Human Thyroid Cancer Tissue)
WB (Western Blot)
(Anti-CUEDC2 antibody, AAA45375, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human CuEDC2, 28.9KD(162aa tag+ N197-H287)Lane 1: Recombinant Human CuEDC2 Protein 10ngLane 2: Recombinant Human CuEDC2 Protein 5ngLane 3: Recombinant Human CuEDC2 Protein 2.5ngLane 4: Recombinant Human CuEDC2 Protein 1.25ng)
WB (Western Blot)
(Anti-CUEDC2 antibody, AAA45375, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human CuEDC2, 28.9KD(162aa tag+ N197-H287)Lane 1: Recombinant Human CuEDC2 Protein 10ngLane 2: Recombinant Human CuEDC2 Protein 5ngLane 3: Recombinant Human CuEDC2 Protein 2.5ngLane 4: Recombinant Human CuEDC2 Protein 1.25ng)
Related Product Information for anti-CUEDC2 antibody
Description: Rabbit IgG polyclonal antibody for CUE domain-containing protein 2(CUEDC2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: CUEDC2(Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor(PR, or PGR) and estrogen receptor(ER)-alpha. Hartz(2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence(GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al.(2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.
Background: CUEDC2(Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor(PR, or PGR) and estrogen receptor(ER)-alpha. Hartz(2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence(GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al.(2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
32,009 Da
NCBI Official Full Name
CUE domain-containing protein 2
NCBI Official Synonym Full Names
CUE domain containing 2
NCBI Official Symbol
CUEDC2
NCBI Official Synonym Symbols
C10orf66; bA18I14.5
NCBI Protein Information
CUE domain-containing protein 2
UniProt Protein Name
CUE domain-containing protein 2
UniProt Gene Name
CUEDC2
UniProt Synonym Gene Names
C10orf66
UniProt Entry Name
CUED2_HUMAN
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Product Notes
The CUEDC2 cuedc2 (Catalog #AAA45375) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CUEDC2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CUEDC2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CUEDC2 cuedc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CUEDC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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