IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human gastric cancer using CEACAM-1/CD66a Polyclonal Antibody at dilution of 1:1500.)
Rabbit anti-Human CEACAM-1/CD66a Polyclonal Antibody | anti-CEACAM-1/CD66a antibody
CEACAM-1/CD66a Polyclonal Antibody
Gene Names
Ceacam1; Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
CEACAM-1/CD66a, Antibody; CEACAM-1/CD66a Polyclonal Antibody; bb-1; BGP-1; BGPI; Biliary glycoprotein adhesion molecule; Carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Cc1; C-CAM; CD66a antigen; Cea1; Cea-1; Cea7; Cea-7; CEAM1; Hv2; Hv-2; mCEA1; Mhv-1; mmCGM1; mmCGM1a; mmCGM2; Antigen CD; meconium antigen; Biliary glycoprotein; Carcinoembryonic antigen-related cell adhesion molecule; MHVR; CEACAM; Antigen CD66; BGP 1; Biliary glycoprotein 1; Biliary glycoprotein D; Carcinoembryonic antigen-related cell adhesion molecule 1; CD66a; meconium antigen 100; MHV-R; MHVR1; Murine hepatitis virus receptor; Bgp; Bgp1; Ceacam1; CEACAM-1; CEACAM-2; BGP; CEA-1; anti-CEACAM-1/CD66a antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Concentration
1mg/mL (varies by lot)
Applicable Applications for anti-CEACAM-1/CD66a antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant Mouse CEACAM-1/CD66a protein expressed by E coli
Preparation and Storage
Store at -20 degree C Valid for 12 months. Avoid freeze/thaw cycles. Protected from prolonged exposure to light.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human gastric cancer using CEACAM-1/CD66a Polyclonal Antibody at dilution of 1:1500.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human gastric cancer using CEACAM-1/CD66a Polyclonal Antibody at dilution of 1:1500.)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human lung cancer using CEACAM-1/CD66a Polyclonal Antibody at dilution of 1:1500.)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human lung cancer using CEACAM-1/CD66a Polyclonal Antibody at dilution of 1:1500.)
Related Product Information for anti-CEACAM-1/CD66a antibody
Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM-1; also called BGP and designated CD66a) is a 160 kDa member of the CEACAM branch of the CEA gene family of the immunoglobulin superfamily. It is one of seven human CEACAM subfamily genes that are essentially divided equally between type I transmembrane proteins (CEACAM-1, 3, and 4) and GPI-linked molecules (CEACAM-5-8). There is no CEACAM-2 in human. The gene for human CEACAM-1 codes for a 526 amino acid (aa) type I transmembrane protein that contains a 34 aa signal sequence, a 394 aa extracellular domain (ECD), a 24 aa transmembrane segment, and a 74 aa cytoplasmic region. The ECD contains one N-terminal V-type Ig-like domain, followed by three C2-type Ig-like domains. It shows considerable glycosylation, including high mannose residues and (sialyl) LewisX. The cytoplasmic region shows one ITIM motif and a calmodulin binding site. In addition to the full length form, ten alternate splice forms have been reported. There are three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. All ten alternate splice forms contain the V?type Ig-like domain (aa's 35-142). The three soluble forms also contain the first two C2-type Ig-like domains (aa's 145-317), with differences coming in the third C2-type Ig-like domain. The seven transmembrane isoforms are highly divergent. Five of the seven contain the V-type plus the first two C2-type domains and then diverge considerably both in the ECD and cytoplasmic region. The remaining two contain only the V-type Ig-like domain, the transmembrane region, and either a full-length or truncated cytoplasmic tail. The actual functions of the isoforms are unclear. Full-length mouse and rat CEACAM-1 are approximately 57% aa identical to human CEACAM-1; in the V-type Ig-like domain, they are 58% and 56% aa identical, respectively. The full-length molecule is found on neutrophils, bile duct epithelium, activated NK cells, colonic columnar epithelium and endothelium. It is known to act as an intercellular adhesion molecule, forming both homotypic, and heterotypic bonds with CEA and CEACAM-6/NCA. On neutrophils, CEACAM-1 also binds to dendritic cell CD-SIGN via its LeX moiety, inducing dendritic cell maturation and a subsequent Th1-type response.
Product Categories/Family for anti-CEACAM-1/CD66a antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,271 Da
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 1
NCBI Official Symbol
Ceacam1
NCBI Official Synonym Symbols
Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 1; BGP-1; MHV-R; biliary glycoprotein 1; biliary glycoprotein D; hepatitis virus receptor; carcinoembryonic antigen 1; carcinoembryonic antigen 7; murine hepatitis virus receptor; CEA-related cell ad
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 1
UniProt Gene Name
Ceacam1
UniProt Synonym Gene Names
BGP-1; MHV-R
Similar Products
Product Notes
The CEACAM-1/CD66a ceacam1 (Catalog #AAA179748) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CEACAM-1/CD66a Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CEACAM-1/CD66a can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CEACAM-1/CD66a ceacam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CEACAM-1/CD66a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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