Rabbit BMP-2 Polyclonal Antibody | anti-BMP-2 antibody

RABBIT ANTI HUMAN BMP-2

Cat. Num. AAA49981

• Gene Names: BMP2; BDA2; BMP2A
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
• Synonyms: BMP-2, Antibody; RABBIT ANTI HUMAN BMP-2; anti-BMP-2 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 396

• Applicable Applications for anti-BMP-2 antibody: WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), ELISA
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Buffer Solution: Phosphate buffered saline
• Antiserum Preparation: Antisera to human BMP-2 were raised by repeated immunisations of rabbits with highly purified antigen.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Application Data

(U-2 osteosarcoma cells stained with Rabbit anti Human BMP-2 (AAA49981) green, tubulin, red and nuclei, blue)

Application Data

(Staining of formalin fixed, paraffin embedded human colo-rectal adenocarcinoma with Rabbit anti Human BMP-2 (AAA49981))

Application Data

(Staining of formalin fixed, paraffin embedded human colo-rectal adenocarcinoma with Rabbit anti Human BMP-2 (AAA49981))

Related Product Information for anti-BMP-2 antibody

Rabbit anti Human BMP-2 antibody recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 2 (BMP-2/BMP-2a), full-length 396 amino acids. BMP-2 is a member of the Transforming Growth Factor beta (TGF-B) superfamily and one of a growing number of osteogenic proteins shown to induce bone and cartilage formation and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis. BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation. The realization that BMP-2 was involved in the stimulation of bone formation emerged from research in spinal surgery, following the discovery that the healing of bones was directed by proteins contained within the bone matrix itself.

NCBI and Uniprot Product Information

• NCBI GI #: 4557369
• NCBI GeneID: 650
• NCBI Accession #: NP_001191.1
• NCBI GenBank Nucleotide #: NM_001200.2
• UniProt Accession #: P12643
• Molecular Weight: 44,702 Da
• NCBI Official Full Name: bone morphogenetic protein 2 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 2
• NCBI Official Symbol: BMP2
• NCBI Official Synonym Symbols: BDA2; BMP2A
• NCBI Protein Information: bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
• UniProt Protein Name: Bone morphogenetic protein 2
• UniProt Gene Name: BMP2
• UniProt Synonym Gene Names: BMP2A; BMP-2; BMP-2A
• UniProt Entry Name: BMP2_HUMAN