IHC (Immunohiostchemistry)
(Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2.5 ug/mL.)
Rabbit ASAH1 Polyclonal Antibody | anti-ASAH1 antibody
ASAH1 Antibody
Gene Names
ASAH1; AC; PHP; ASAH; PHP32; ACDase; SMAPME
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
ASAH1, Antibody; ASAH1 Antibody; N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 1, acid ceramidase; anti-ASAH1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
546
Applicable Applications for anti-ASAH1 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 16 amino acid peptide near the carboxy terminus of the human ASAH1.
Target Name
ASAH1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of ASAH1 in mouse heart tissue lysate with ASAH1 antibody at (A) 1 and (B) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of ASAH1 in mouse heart tissue lysate with ASAH1 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-ASAH1 antibody
Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Product Categories/Family for anti-ASAH1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
44,046 Da
NCBI Official Full Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1, isoform CRA_c
NCBI Official Synonym Full Names
N-acylsphingosine amidohydrolase (acid ceramidase) 1
NCBI Official Symbol
ASAH1
NCBI Official Synonym Symbols
AC; PHP; ASAH; PHP32; ACDase; SMAPME
NCBI Protein Information
acid ceramidase
UniProt Protein Name
Acid ceramidase
UniProt Gene Name
ASAH1
UniProt Synonym Gene Names
ASAH; AC; ACDase; Acid CDase; PHP32
UniProt Entry Name
ASAH1_HUMAN
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Product Notes
The ASAH1 asah1 (Catalog #AAA307153) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASAH1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ASAH1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the ASAH1 asah1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASAH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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