SDS-PAGE
Major vault protein Recombinant Protein | MVP recombinant protein
Recombinant Human Major vault protein
Gene Names
MVP; LRP; VAULT1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Major vault protein; N/A; Recombinant Human Major vault protein; Lung resistance-related protein; MVP recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-893aa; Full Length of Mature Protein
Sequence
ATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQ
APGDNHVVPVLR
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for MVP recombinant protein
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Product Categories/Family for MVP recombinant protein
References
The drug resistance-related protein LRP is the human major vault protein.Scheffer G.L., Wijngaard P.L.J., Flens M.J., Izquierdo M.A., Slovak M.L., Pinedo H.M., Meijer C.J.L.M., Clevers H.C., Scheper R.J.Nat. Med. 1:578-582(1995) Scheffer G.L. Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter.Lange C., Walther W., Schwabe H., Stein U.Biochem. Biophys. Res. Commun. 278:125-133(2000) A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant.Holzmann K., Ambrosch I., Elbling L., Micksche M., Berger W.FEBS Lett. 494:99-104(2001) Quadroni M., Potts A., Barblan J., Bienvenut W.V.Submitted (JAN-2005) to UniProtKB Vaults and telomerase share a common subunit, TEP1.Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H.J. Biol. Chem. 274:32712-32717(1999) PTEN associates with the vault particles in HeLa cells.Yu Z., Fotouhi-Ardakani N., Wu L., Maoui M., Wang S., Banville D., Shen S.-H.J. Biol. Chem. 277:40247-40252(2002) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.Kolli S., Zito C.I., Mossink M.H., Wiemer E.A.C., Bennett A.M.J. Biol. Chem. 279:29374-29385(2004) A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway.Xiang Z., Yuan W., Luo N., Wang Y., Tan K., Deng Y., Zhou X., Zhu C., Li Y., Liu M., Wu X., Li Y.Biochem. Biophys. Res. Commun. 347:288-296(2006) Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling.Kim E., Lee S., Mian M.F., Yun S.U., Song M., Yi K.-S., Ryu S.H., Suh P.-G.FEBS J. 273:793-804(2006) The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals.Steiner E., Holzmann K., Pirker C., Elbling L., Micksche M., Sutterluety H., Berger W.J. Cell Sci. 119:459-469(2006) Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.Chattopadhyay R., Das S., Maiti A.K., Boldogh I., Xie J., Hazra T.K., Kohno K., Mitra S., Bhakat K.K.Mol. Cell. Biol. 28:7066-7080(2008) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Solution structure of a two-repeat fragment of major vault protein.Kozlov G., Vavelyuk O., Minailiuc O., Banville D., Gehring K., Ekiel I.J. Mol. Biol. 356:444-452(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
115.2 kDa
NCBI Official Full Name
major vault protein isoform 2
NCBI Official Synonym Full Names
major vault protein
NCBI Official Symbol
MVP
NCBI Official Synonym Symbols
LRP; VAULT1
NCBI Protein Information
major vault protein
UniProt Protein Name
Major vault protein
UniProt Gene Name
MVP
UniProt Synonym Gene Names
LRP; MVP
UniProt Entry Name
MVP_HUMAN
Similar Products
Product Notes
The MVP mvp (Catalog #AAA117248) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-893aa; Full Length of Mature Protein. The amino acid sequence is listed below: ATEEFIIRIP PYHYIHVLDQ NSNVSRVEVG PKTYIRQDNE RVLFAPMRMV TVPPRHYCTV ANPVSRDAQG LVLFDVTGQV RLRHADLEIR LAQDPFPLYP GEVLEKDITP LQVVLPNTAL HLKALLDFED KDGDKVVAGD EWLFEGPGTY IPRKEVEVVE IIQATIIRQN QALRLRARKE CWDRDGKERV TGEEWLVTTV GAYLPAVFEE VLDLVDAVIL TEKTALHLRA RRNFRDFRGV SRRTGEEWLV TVQDTEAHVP DVHEEVLGVV PITTLGPHNY CVILDPVGPD GKNQLGQKRV VKGEKSFFLQ PGEQLEQGIQ DVYVLSEQQG LLLRALQPLE EGEDEEKVSH QAGDHWLIRG PLEYVPSAKV EVVEERQAIP LDENEGIYVQ DVKTGKVRAV IGSTYMLTQD EVLWEKELPP GVEELLNKGQ DPLADRGEKD TAKSLQPLAP RNKTRVVSYR VPHNAAVQVY DYREKRARVV FGPELVSLGP EEQFTVLSLS AGRPKRPHAR RALCLLLGPD FFTDVITIET ADHARLQLQL AYNWHFEVND RKDPQETAKL FSVPDFVGDA CKAIASRVRG AVASVTFDDF HKNSARIIRT AVFGFETSEA KGPDGMALPR PRDQAVFPQN GLVVSSVDVQ SVEPVDQRTR DALQRSVQLA IEITTNSQEA AAKHEAQRLE QEARGRLERQ KILDQSEAEK ARKELLELEA LSMAVESTGT AKAEAESRAE AARIEGEGSV LQAKLKAQAL AIETEAELQR VQKVRELELV YARAQLELEV SKAQQLAEVE VKKFKQMTEA IGPSTIRDLA VAGPEMQVKL LQSLGLKSTL ITDGSTPINL FNTAFGLLGM GPEGQPLGRR VASGPSPGEG ISPQSAQAPQ APGDNHVVP VLR. It is sometimes possible for the material contained within the vial of "Major vault protein, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.