Application Data
Mouse anti-Human VEGFR-2/KDR Monoclonal Antibody | anti-VEGFR-2/KDR antibody
Mouse Anti-Human VEGFR-2/KDR
Gene Names
KDR; FLK1; CD309; VEGFR; VEGFR2
Reactivity
Human
Applications
Western Blot, Flow Cytometry, Functional Assay, Immunohistochemistry, ELISA
Purity
Protein G Purified
Synonyms
VEGFR-2/KDR, Antibody; Mouse Anti-Human VEGFR-2/KDR; Anti-human VEGFR-2/KDR (#EIC); Vascular endothelial growth factor receptor 2; anti-VEGFR-2/KDR antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
IgG1; EIC
Specificity
The antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types.
Purity/Purification
Protein G Purified
Form/Format
Sterile filtered antibody solution was lyophilized from PBS; does not contain stabilizers or preservatives
Sequence Length
1356
Applicable Applications for anti-VEGFR-2/KDR antibody
WB (Western Blot), FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA
Immunogen
recombinant human soluble KDR (D7) (RT# S01-002)
Preparation
Monoclonal antibodies were produced with the help of BALB/c mice using recombinant human soluble extracellular KDR (D7) as the immunizing antigen
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml
Preparation and Storage
Store at 2-8°C for up to 2 weeks
After initial reconstitution, prepare and store working aliquots at -20 to -80°C
Avoid freeze/thaw cycles
After initial reconstitution, prepare and store working aliquots at -20 to -80°C
Avoid freeze/thaw cycles
Application Data
Application Data
Related Product Information for anti-VEGFR-2/KDR antibody
Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not to our knowledge been previously described. A splice variant of the gene encoding vascular endothelial growth factor receptor-2 (VEGFR-2) that encodes a secreted form of the protein, designated endogenous soluble VEGFR-2 (esVEGFR- 2/KDR) has been described. The endogenous soluble esKDR inhibits developmental and reparative lymphangiogenesis by blocking VEGF-C function. Tissue-specific loss of esKDR in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of esKDR inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring esKDR thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of esKDR might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema.
References
1. Shibata et al, BMC Medicine 8 (2010) 2. Albaquerque et al, Nature Med 2009 3. Ebos et al, Mol Cancer Res 2 (2004) 4. Ebos et al, Cancer res 68 (2008).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~50 kDa HC and ~25 kDa LC
NCBI Official Full Name
vascular endothelial growth factor receptor 2
NCBI Official Synonym Full Names
kinase insert domain receptor (a type III receptor tyrosine kinase)
NCBI Official Symbol
KDR
NCBI Official Synonym Symbols
FLK1; CD309; VEGFR; VEGFR2
NCBI Protein Information
vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor
UniProt Protein Name
Vascular endothelial growth factor receptor 2
UniProt Gene Name
KDR
UniProt Synonym Gene Names
FLK1; VEGFR2; VEGFR-2; FLK-1; KDR
UniProt Entry Name
VGFR2_HUMAN
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Product Notes
The VEGFR-2/KDR kdr (Catalog #AAA79115) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human VEGFR-2/KDR reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VEGFR-2/KDR can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the VEGFR-2/KDR kdr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VEGFR-2/KDR, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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