IHC (Immunohistochemistry)
(Immunohistochemistry: Human placenta (FFPE) stained with Mouse anti- Uroplakin-2 (Cat# AAA71363) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
Mouse anti-Human Uroplakin-2 Monoclonal Antibody | anti-UPK2 antibody
Mouse Anti Uroplakin-2 Monoclonal Antibody
Gene Names
UPK2; UP2; UPII
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
Synonyms
Uroplakin-2, Antibody; Mouse Anti Uroplakin-2 Monoclonal Antibody; anti-UPK2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
ABM146
Specificity
This antibody recognizes human Uroplakin-2 protein. The other species are not tested.
Purity/Purification
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
Form/Format
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer.
Sequence Length
184
Applicable Applications for anti-UPK2 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Antigen Preparation
A synthetic peptide from C-term of human uroplakin-2 protein
Positive Control
Kidney Tissue
Cellular Location
Cell Membrane
Preparation and Storage
The antibodies are stable for 1 year from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles
IHC (Immunohistochemistry)
(Immunohistochemistry: Human placenta (FFPE) stained with Mouse anti- Uroplakin-2 (Cat# AAA71363) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
IHC (Immunohistochemistry)
(Immunohistochemistry: Human placenta (FFPE) stained with Mouse anti- Uroplakin-2 (Cat# AAA71363) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
Related Product Information for anti-UPK2 antibody
Description: Uroplakin-2
Uroplakin-2 is one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. Urothelium is built with dimensional, asymmetric plaques, whose specific structure is crucial for tightness and elasticity of urothelium. Integral components of these plaques are uroplakins (UP).. Several isoforms of UP are known in humans: UP1a, UP1b, UP2, UP3a, UP3b, and UP3c. UP2 with a mass of 15kDa is the smallest UP. In contrast to other UPs, a mature form of UP2 does not consist of any sugar moiety; however its precursor undergoes glycosylation in endoplasmic reticulum. Glycosylation of immature UP2 seems to be crucial in building the dimer with UP1a. UP2 is essential in forming of uroplakins crystals, out of which plaques are built. Studies have shown uroplakin 2 messenger RNA to be expressed in bladder cancer tissues and peripheral blood of patients with urothelial carcinoma.
Uroplakin-2 is one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. Urothelium is built with dimensional, asymmetric plaques, whose specific structure is crucial for tightness and elasticity of urothelium. Integral components of these plaques are uroplakins (UP).. Several isoforms of UP are known in humans: UP1a, UP1b, UP2, UP3a, UP3b, and UP3c. UP2 with a mass of 15kDa is the smallest UP. In contrast to other UPs, a mature form of UP2 does not consist of any sugar moiety; however its precursor undergoes glycosylation in endoplasmic reticulum. Glycosylation of immature UP2 seems to be crucial in building the dimer with UP1a. UP2 is essential in forming of uroplakins crystals, out of which plaques are built. Studies have shown uroplakin 2 messenger RNA to be expressed in bladder cancer tissues and peripheral blood of patients with urothelial carcinoma.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
15.0
NCBI Official Full Name
uroplakin-2
NCBI Official Synonym Full Names
uroplakin 2
NCBI Official Symbol
UPK2
NCBI Official Synonym Symbols
UP2; UPII
NCBI Protein Information
uroplakin-2
UniProt Protein Name
Uroplakin-2
UniProt Gene Name
UPK2
UniProt Synonym Gene Names
UP2; UPII
UniProt Entry Name
UPK2_HUMAN
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Product Notes
The UPK2 upk2 (Catalog #AAA71363) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Uroplakin-2 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Uroplakin-2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the UPK2 upk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Uroplakin-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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