Rat TIM-2 Monoclonal Antibody | anti-TIM-2 antibody

RAT ANTI MOUSE TIM-2:FITC

Cat. Num. AAA50215

• Gene Names: Timd2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662
• Applications: Flow Cytometry, Functional Assay
• Synonyms: TIM-2, Antibody; RAT ANTI MOUSE TIM-2:FITC; anti-TIM-2 antibody

• Host: Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: RMT2-25
• Form/Format: FITC; Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
• Concentration: IgG concentration 0.1 mg/ml (varies by lot)
• Sequence Length: 305

• Applicable Applications for anti-TIM-2 antibody: FCM/FACS (Flow Cytometry)
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin; Preparation
• Immunogen: Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.; Fusion Partners
• Target Species: Mouse
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Application Data

(TIM-2 transfected NRK cells stained with Rat anti Mouse TIM-2:FITC (AAA50215))

Application Data

(TIM-2 transfected NRK cells stained with Rat anti Mouse TIM-2)

Related Product Information for anti-TIM-2 antibody

Rat anti Mouse TIM-2 antibody, clone RMT2-25 recognizes mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation. Studies using Rat anti Mouse TIM-2 antibody, clone RMT2-25 in mouse, have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, during early phase collagen-induced arthritis (Kawamoto et al. 2011). Rat anti Mouse TIM-2 antibody, clone RMT2-25 has been shown to significantly enhance the proliferation of stimulated splenic B cells in vitro (Kawamoto et al. 2011).

NCBI and Uniprot Product Information

• NCBI GI #: 238624136
• NCBI GeneID: 171284
• NCBI Accession #: NP_001154827.1
• NCBI GenBank Nucleotide #: NM_001161355.1
• UniProt Accession #: Q8R183; Q8VBW0
• Molecular Weight: 33,504 Da
• NCBI Official Full Name: T-cell immunoglobulin and mucin domain-containing protein 2
• NCBI Official Synonym Full Names: T cell immunoglobulin and mucin domain containing 2
• NCBI Official Symbol: Timd2
• NCBI Official Synonym Symbols: G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662
• NCBI Protein Information: T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIMD-2
• UniProt Protein Name: T-cell immunoglobulin and mucin domain-containing protein 2
• UniProt Gene Name: Timd2
• UniProt Synonym Gene Names: Tim2; TIMD-2; TIM-2
• UniProt Entry Name: TIMD2_MOUSE