Application Data
Mouse SHP2 (N-terminal Region) Monoclonal Antibody
Anti-SHP2 (N-terminal region)
Reactivity
Human, Rat, Mouse
Applications
Western Blot, ELISA
Purity
Protein A Purified
Synonyms
SHP2 (N-terminal Region), Antibody; Anti-SHP2 (N-terminal region); SHP2 (N-terminal Region); PTP-1D; SH-PTP2; Syp; SHP-2; anti-SHP2 (N-terminal Region) antibody
Host
Mouse
Reactivity
Human, Rat, Mouse
Clonality
Monoclonal
Isotype
IgG1
Specificity
The antibody detects a 72 kDa* protein in human A431 and Jurkat cells, and mouse brain. This antibody does not cross-react with SHP1.
Purity/Purification
Protein A Purified
Form/Format
Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Applicable Applications for anti-SHP2 (N-terminal Region) antibody
WB (Western Blot), ELISA
Immunogen
Clone (M163) was generated from a recombinant protein containing amino acids in the N-terminal region of human SHP1. This sequence is highly conserved in rat and mouse SHP1.
Preparation and Storage
Store at -20 degree C. Do not aliquot.
Application Data
Application Data
Related Product Information for anti-SHP2 (N-terminal Region) antibody
SHP1 (PTP1C, SH-PTP1, or HCP) is a protein-tyrosine phosphatase (PTP) involved in cell migration, cell proliferation, and immune cell function. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP1 associates with a variety of cytokine and growth factor receptors and regulates signal transduction through dephosphorylation of these receptors or their downstream effectors. Downstream of receptor activation, SHP1 regulates the transcriptional activity stimulated by JAK/Stat and MAPK pathways. SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr-564 stimulates phosphatase activity and promotes interaction with Grb-2. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity. Thus, phosphorylation at tyrosine relative to serine residues may be regulated by different cell signaling pathways to control SHP1 activity.
References
• Qu, C.K. (2000) Cell Res. 10:279.
• Maroun, C. R. et al. (2000) Mol. Cell. Biol. 20:8513.
• Zhang, S. Q. et al. (2002) Mol. Cell. Biol. 22:4062.
• Maroun, C. R. et al. (2000) Mol. Cell. Biol. 20:8513.
• Zhang, S. Q. et al. (2002) Mol. Cell. Biol. 22:4062.
Similar Products
Product Notes
The SHP2 (N-terminal Region) (Catalog #AAA71508) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-SHP2 (N-terminal region) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SHP2 (N-terminal Region) can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SHP2 (N-terminal Region) for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHP2 (N-terminal Region), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.