IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMS2 Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).)
Rabbit anti-Human PMS2 (Postmeiotic Segregation Increased 2) Monoclonal Antibody | anti-PMS2 antibody
PMS2 (Postmeiotic Segregation Increased 2) Recombinant Rabbit Monoclonal Antibody [Clone PMS2/4373R]
Gene Names
PMS2; PMSL2; HNPCC4; PMS2CL
Reactivity
Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, Flow Cytometry, Functional Assay
Synonyms
PMS2 (Postmeiotic Segregation Increased 2), Antibody; PMS2 (Postmeiotic Segregation Increased 2) Recombinant Rabbit Monoclonal Antibody [Clone PMS2/4373R]; DNA mismatch repair protein PMS2; hereditary non-polyposis colorectal cancer type 4 (HNPCC4); Mismatch repair gene PMSL2; PMS1 protein homolog 2; postmeiotic segregation increased 2 (S. cerevisiae); PMS2CL; anti-PMS2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit/IgG
Clone Number
PMS2/4373R
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-PMS2 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), WB (Western Blot), FCM/FACS (Flow Cytometry)
Antibody Type
Recombinant Antibody
Immunogen
A synthetic peptide corresponding to residues within aa1-100 of human PMS2 (exact sequence is proprietary)
Cellular Localization
Nuclear
Positive Control
HeLa or Jurkat cells. Human colon carcinoma.
Hu-chromosome Location
7p22.2
Unigene
632637
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMS2 Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMS2 Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).)
Related Product Information for anti-PMS2 antibody
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS); also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
95,797 Da
NCBI Official Full Name
mismatch repair endonuclease PMS2 isoform a
NCBI Official Synonym Full Names
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
NCBI Official Symbol
PMS2
NCBI Official Synonym Symbols
PMSL2; HNPCC4; PMS2CL
NCBI Protein Information
mismatch repair endonuclease PMS2; H_DJ0042M02.9; PMS1 protein homolog 2; DNA mismatch repair protein PMS2
UniProt Protein Name
Mismatch repair endonuclease PMS2
UniProt Gene Name
PMS2
UniProt Synonym Gene Names
PMSL2
UniProt Entry Name
PMS2_HUMAN
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Product Notes
The PMS2 pms2 (Catalog #AAA215841) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PMS2 (Postmeiotic Segregation Increased 2) Recombinant Rabbit Monoclonal Antibody [Clone PMS2/4373R] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PMS2 (Postmeiotic Segregation Increased 2) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), WB (Western Blot), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the PMS2 pms2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PMS2 (Postmeiotic Segregation Increased 2), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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