Mouse anti-Human HLA-DR/DP/DQ Monoclonal Antibody | anti-HLA-DR/DP/DQ antibody

Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]

Cat. Num. AAA213513

• Gene Names: HLA-DRA; MLRW; HLA-DRA1
• Reactivity: Human
• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: HLA-DR/DP/DQ, Antibody; Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]; MHC class II antigen DRA; HLA-DRA1; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; major histocompatibility complex, class II, DR alpha; anti-HLA-DR/DP/DQ antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: CR3/43
• Purity/Purification: Purified
• Form/Format: Liquid. Whole IgG. Phosphate Buffered Saline (PBS) with 0.1% BSA and 0.09% Sodium Azide
• Concentration: 250ug/ml (varies by lot)

• Applicable Applications for anti-HLA-DR/DP/DQ antibody: ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Cells from human tonsil
• Conjugation: Unconjugated
• Preparation and Storage: Store at 2-8 degree C; Shelf Life: 1 year from date of receipt

WB (Western Blot)

(Detection of human HLA-DR/DP/DQ by western blot. Samples: Whole cell lysate (50 ug) from Ramos, KG-1, and Raji (10 ug) cells prepared using NETN lysis buffer. Antibody: Mouse anti-HLA-DR/DP/DQ monoclonal antibody [CR3-43] (AAA213513 lot 1) used at 1:1000. Secondary: HRP-conjugated goat anti-mouse IgG . Detection: Chemiluminescence with an exposure time of 30 seconds. Lower Panel: Rabbit anti-Actin recombinant monoclonal antibody .)

IHC (Immunohistochemisry)

(Detection of human HLA/DR/DP/DQ by immunohistochemistry. Sample: FFPE section of liver carcinoma. Antibody: Mouse anti-HLA/DR/DP/DQ monoclonal antibody [CR3/43] (AAA213513-1). Secondary: HRP-conjugated goat anti-mouse IgG .)

IHC (Immunohiostchemistry)

(Detection of human HLA/DR/DP/DQ by immunohistochemistry. Sample: FFPE section of tonsil. Antibody: Mouse anti-HLA/DR/DP/DQ monoclonal antibody [CR3/43] (AAA213513-1). Secondary: HRP-conjugated goat anti-mouse IgG .)

ICC (Immunocytochemistry)

(Detection of human HLA/DR/DP/DQ by immunocytochemistry. Sample: FFPE section of VLN3G2 cells. Antibody: Mouse anti-HLA/DR/DP/DQ monoclonal antibody [CR3/43] (AAA213513-1). Secondary: HRP-conjugated goat anti-mouse IgG .)

Related Product Information for anti-HLA-DR/DP/DQ antibody

In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR,-DQ, and-DP, which display ?70% similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an alpha (heavy) chain and a beta (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.

Product Categories/Family for anti-HLA-DR/DP/DQ antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 52426774
• NCBI GeneID: 3122
• NCBI Accession #: NP_061984.2
• NCBI GenBank Nucleotide #: NM_019111.4
• UniProt Accession #: P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70; A2BET4
• Molecular Weight: 28,607 Da
• NCBI Official Full Name: HLA class II histocompatibility antigen, DR alpha chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DR alpha
• NCBI Official Symbol: HLA-DRA
• NCBI Official Synonym Symbols: MLRW; HLA-DRA1
• NCBI Protein Information: HLA class II histocompatibility antigen, DR alpha chain; MHC cell surface glycoprotein; MHC class II antigen DRA; histocompatibility antigen HLA-DR alpha
• UniProt Protein Name: HLA class II histocompatibility antigen, DR alpha chain
• UniProt Gene Name: HLA-DRA
• UniProt Synonym Gene Names: HLA-DRA1
• UniProt Entry Name: DRA_HUMAN