IHC (Immunohiostchemistry)
(Claudin-7 Antibody Immunohistochemistry on an FFPE Transitonal Cell Carcinoma Tissue)
Rabbit anti-Human Claudin-7 Monoclonal Antibody
Claudin-7 (EP399)
Reactivity
Human
Synonyms
Claudin-7, Antibody; Claudin-7 (EP399); claudin-7; claudin 7; cldn7; cldn-7; anti-claudin-7; anti-claudin 7; anti-cldn7; anti-cldn-7; anti-Claudin-7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP399
Form/Format
Paraffin, Frozen
Claudin-7 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Claudin-7 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues of the human Claudin-7 protein.
Control
Breast, Colon, Falopian Tube, Pancreas, Kidney, Transitional Cell Carcinoma
Localization
Cytoplasmic, Nuclear, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(Claudin-7 Antibody Immunohistochemistry on an FFPE Transitonal Cell Carcinoma Tissue)
IHC (Immunohiostchemistry)
(Claudin-7 Antibody Immunohistochemistry on an FFPE Transitonal Cell Carcinoma Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-Claudin-7 antibody
Claudin-7 is encoded by the CLDN7 gene and is a member of the claudin family. Claudin-7 is a component of tight junctions and plays important roles in maintaining cell polarity and tightly connecting the barriers between cells. Abnormal Claudin-7 protein expression is closely related to tumor occurrence, development, and metastasis. Claudin-7 expression is down-regulated in Colorectal Cancer (CRC) and Lung Cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis.
Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.
Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.
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Product Notes
The Claudin-7 (Catalog #AAA59363) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Claudin-7 (EP399) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Claudin-7, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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