SDS-PAGE
(SDS-PAGE Analysis Purified CD41a Mouse Monoclonal Antibody (ITGA2B/1036). Confirmation of Integrity and Purity of Antibody.)
Mouse CD41a / Integrin alpha2b Monoclonal Antibody | anti-ITGA2B antibody
CD41a / Integrin alpha2b (Platelet Marker) Mouse Monoclonal Antibody
Gene Names
ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
Reactivity
Human, Others not tested
Applications
Immunofluorescence, Flow Cytometry, Functional Assay
Synonyms
CD41a / Integrin alpha2b, Antibody; CD41a / Integrin alpha2b (Platelet Marker) Mouse Monoclonal Antibody; BDPLT16; BDPLT2; GPalpha IIb; GT; HPA3; Integrin alpha IIb; ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; anti-ITGA2B antibody
Host
Mouse
Reactivity
Human, Others not tested
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
ITGA2B/1036
Specificity
Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
1039
Applicable Applications for anti-ITGA2B antibody
IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
Cellular Localization
Cell Surface
Immunogen
Recombinant full-length human Integrin alpha IIb protein
Hu-Chromosome Location
17q21.32
Positive Control
KG1a, HEL cells, and human platelets in lymph nodes or tonsils.
Preparation and Storage
Antibody with azide - store at 2°C to 8°C. Antibody without azide - store at -20°C to -80°C. Non-hazardous. No MSDS required.
SDS-PAGE
(SDS-PAGE Analysis Purified CD41a Mouse Monoclonal Antibody (ITGA2B/1036). Confirmation of Integrity and Purity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified CD41a Mouse Monoclonal Antibody (ITGA2B/1036). Confirmation of Integrity and Purity of Antibody.)
References
McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995. Smith JW et al. Interaction of integrins v3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271. Du XP et al. Ligands activate integrin IIb/3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416. Law DA et al. Outside-in integrin signal transduction. IIb/3-(GP IIb/IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996, 271(18):10811-10815. Moroi M and Jung SM. Integrin-mediated platelet adhesion. Front Biosci 1998, 3:D719-728
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
90kDa
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin subunit alpha 2b
NCBI Official Symbol
ITGA2B
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Gene Name
ITGA2B
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb
UniProt Entry Name
ITA2B_HUMAN
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Product Notes
The ITGA2B itga2b (Catalog #AAA62833) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD41a / Integrin alpha2b (Platelet Marker) Mouse Monoclonal Antibody reacts with Human, Others not tested and may cross-react with other species as described in the data sheet. AAA Biotech's CD41a / Integrin alpha2b can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the ITGA2B itga2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD41a / Integrin alpha2b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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