Application Data
(BALB/c mouse bone marrow cells were stained with Rat Anti-Mouse CD11b-APC (AAA78668))
Rat anti-Mouse CD11b/Mac-1 Monoclonal Antibody | anti-ITGAM antibody
Rat Anti-Mouse CD11b/Mac-1a-APC
Gene Names
ITGAM; CR3; C3bi; CD11B
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD11b/Mac-1, Antibody; Rat Anti-Mouse CD11b/Mac-1a-APC; Integrin αM, Mac-1α, Mac-1, Mo1, CR3, C3biR; anti-ITGAM antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat (Lewis) IgG2a kappa
Clone Number
3A33
Specificity
Mouse CD11b; Mr 170 kDa
Form/Format
The allophycocyanin (APC) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent.
Sequence Length
1152
Applicable Applications for anti-ITGAM antibody
FCM/FACS (Flow Cytometry)
Immunogen
Peritoneal macrophages from B6D2 hybrid mice.
Preparation and Storage
Store at 2-8°C. DO NOT FREEZE.
Application Data
(BALB/c mouse bone marrow cells were stained with Rat Anti-Mouse CD11b-APC (AAA78668))
Application Data
(BALB/c mouse bone marrow cells were stained with Rat Anti-Mouse CD11b-APC (AAA78668))
Related Product Information for anti-ITGAM antibody
Description: CD11b (integrin αM subunit) combines with CD18 (integrin ?2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
References
1. Martin, A., R. Le Corre, P. Pellen,, D. Bourel, G. Merdrignac, B. Genetet, and L. Toujas. 1986. Tissue Antigens 28:15.
2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.
3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.
4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.
5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.
6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.
7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.
8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.
9. Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shrotman. 1992. J. Exp. Med. 176:47.
10. Leenen, P.J. M., M.F.T.R. de Bruijn, J.S.A. Voerman, P.A. Campbell, and W. van Ewijk. 1994. J. Immunol. Meth. 174:5.
11. Gresham, H.D., et al. 1991. J. Clin. Invest. 88:588.
12. Springer, T.A. 1994. Cell 76:310.
2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.
3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.
4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.
5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.
6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.
7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.
8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.
9. Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shrotman. 1992. J. Exp. Med. 176:47.
10. Leenen, P.J. M., M.F.T.R. de Bruijn, J.S.A. Voerman, P.A. Campbell, and W. van Ewijk. 1994. J. Immunol. Meth. 174:5.
11. Gresham, H.D., et al. 1991. J. Clin. Invest. 88:588.
12. Springer, T.A. 1994. Cell 76:310.
NCBI and Uniprot Product Information
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Product Notes
The ITGAM (Catalog #AAA78668) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse CD11b/Mac-1a-APC reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD11b/Mac-1 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the ITGAM for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11b/Mac-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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