Bioactivity
(Human Epiregulin stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cells. The ED50 range )
Epiregulin Recombinant Protein | EREG recombinant protein
Recombinant human Epiregulin protein
Gene Names
EREG; ER; Ep; EPR
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
Epiregulin; N/A; Recombinant human Epiregulin protein; Ep; EPR; ER; Proepiregulin; EREG; EREG recombinant protein
Host
HEK293
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence Positions
63-108aa
Sequence
Applicable Applications for EREG recombinant protein
Bioactivity, SDS-PAGE
Species
Human
Tag
hIgG-His-Tag
Predicted Nterm
Asp
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 range <= 1 ug/ml.
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Bioactivity
(Human Epiregulin stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cells. The ED50 range )
Bioactivity
(Human Epiregulin stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cells. The ED50 range )
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
Related Product Information for EREG recombinant protein
Epiregulin is a member of the epidermal growth factor family. It is expressed primarily in the placenta and macrophages and high level expression has also been detected in various carcinomas. This protein contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. Epiregulin is growth factors involved in cancer development. Deregulated epiregulin activity appears to contribute to the progression of a number of different malignancies, including cancers of the bladder, stomach, colon, breast, lung, head and neck, and liver. It inhibit the growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various other types of cells. In addition, it has been implicated in the implantation process during pregnancy. Recombinant human Epiregulin, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Categories/Family for EREG recombinant protein
References
Shaowei Li., et al, (2008) Anticancer Res. 105:3539-3544. ;; Yamamoto T., et al, (2004) Anticancer Res. 24:2007-2010.;; Cho MC., et al, (2008) Biochem. Biophys. Res. 377:832-837.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19,044 Da
NCBI Official Full Name
proepiregulin preproprotein
NCBI Official Synonym Full Names
epiregulin
NCBI Official Symbol
EREG
NCBI Official Synonym Symbols
ER; Ep; EPR
NCBI Protein Information
proepiregulin
UniProt Protein Name
Proepiregulin
UniProt Gene Name
EREG
UniProt Synonym Gene Names
EPR
UniProt Entry Name
EREG_HUMAN
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Product Notes
The EREG ereg (Catalog #AAA48415) is a Recombinant Protein produced from HEK293 and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 63-108aa. AAA Biotech's Epiregulin can be used in a range of immunoassay formats including, but not limited to, Bioactivity, SDS-PAGE. Researchers should empirically determine the suitability of the EREG ereg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below:Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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