Cysteine and glycine-rich protein 3 (CSRP3) Recombinant Protein | CSRP3 recombinant protein

Recombinant Human Cysteine and glycine-rich protein 3 (CSRP3)

Cat. Num. AAA114039

• Gene Names: CSRP3; CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cysteine and glycine-rich protein 3 (CSRP3); N/A; Recombinant Human Cysteine and glycine-rich protein 3 (CSRP3); Cardiac LIM protein; Cysteine-rich protein 3; CRP3; LIM domain protein, cardiac; Muscle LIM protein; CSRP3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-194. Full Length
• Sequence: MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for CSRP3 recombinant protein

Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.

Product Categories/Family for CSRP3 recombinant protein

Developmental Biology

References

Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization.Fung Y.W., Wang R.X., Heng H.H.Q., Liew C.C.Genomics 28:602-603(1995) Cloning of the gene encoding the human muscle LIM protein, a regulator of myogenesis.Medvedev A., Jetten A.M. Cloning and characterization of the human muscle LIM protein gene.Yasunaga S., Harada H., Kimura A.A novel member of LIM gene family involved in cardiovascular diseases.Chen K.H., Zhang J.F., Ma D.L., Tang J. Structure and dynamics of the human muscle LIM protein.Schallus T., Feher K., Ulrich A.S., Stier G., Muhle-Goll C.FEBS Lett. 583:1017-1022(2009) The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.Knoell R., Hoshijima M., Hoffman H.M., Person V., Lorenzen-Schmidt I., Bang M.-L., Hayashi T., Shiga N., Yasukawa H., Schaper W., McKenna W., Yokoyama M., Schork N.J., Omens J.H., McCulloch A.D., Kimura A., Gregorio C.C., Poller W., Schaper J., Schultheiss H.P., Chien K.R.Cell 111:943-955(2002) Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.Geier C., Perrot A., Ozcelik C., Binner P., Counsell D., Hoffmann K., Pilz B., Martiniak Y., Gehmlich K., van der Ven P.F.M., Furst D.O., Vornwald A., von Hodenberg E., Nurnberg P., Scheffold T., Dietz R., Osterziel K.J.Circulation 107:1390-1395(2003) Beyond the sarcomere CSRP3 mutations cause hypertrophic cardiomyopathy.Geier C., Gehmlich K., Ehler E., Hassfeld S., Perrot A., Hayess K., Cardim N., Wenzel K., Erdmann B., Krackhardt F., Posch M.G., Osterziel K.J., Bublak A., Nagele H., Scheffold T., Dietz R., Chien K.R., Spuler S., Furst D.O., Nurnberg P., Ozcelik C.Hum. Mol. Genet. 17:2753-2765(2008)

NCBI and Uniprot Product Information

• NCBI GI #: 4502893
• NCBI GeneID: 8048
• NCBI Accession #: NP_003467.1
• NCBI GenBank Nucleotide #: NM_003476.4
• UniProt Accession #: P50461; Q9P131
• Molecular Weight: 37 kDa
• NCBI Official Full Name: cysteine and glycine-rich protein 3
• NCBI Official Synonym Full Names: cysteine and glycine rich protein 3
• NCBI Official Symbol: CSRP3
• NCBI Official Synonym Symbols: CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• NCBI Protein Information: cysteine and glycine-rich protein 3
• UniProt Protein Name: Cysteine and glycine-rich protein 3
• UniProt Gene Name: CSRP3
• UniProt Synonym Gene Names: CLP; MLP; CRP3
• UniProt Entry Name: CSRP3_HUMAN