Application Data
(Image: Western blot analysis of extracts from various cell types using TCF4 (C48H11) Rabbit mAb.)
TCF4 (C48H11) Antibody | anti-TCF4 antibody
TCF4 (C48H11), Monoclonal Antibody, Rabbit
Gene Names
TCF4; E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
Reactivity
Chicken, Human, Mouse, Rat
Applications
Immunoprecipitation, Western Blot
Synonyms
TCF4 (C48H11); N/A; TCF4 (C48H11), Monoclonal Antibody, Rabbit; anti-TCF4 antibody
Reactivity
Chicken, Human, Mouse, Rat
Specificity
TCF4 (C48H11) Rabbit mAb detects endogenous levels of total TCF4 protein.
Form/Format
Liquid in 10mM sodium HEPES (pH7.5), 150mM NaCl, 100ug BSA and 50% glycerol.
Sequence Length
773
Applicable Applications for anti-TCF4 antibody
IP (Immunoprecipitation), WB (Western Blot)
Type Info
Rabbit IgG
Immunogen
Synthetic peptide (KLH-coupled) corresponding to (KLH-coupled) corresponding to Leu330 of human TCF4.
Preparation and Storage
Storeat -20ºC. Do not aliquot the antibody. Stable for up to at least 6 months. Repeated freeze/thaw cycles compromise the integrity of the antiserum.
Application Data
(Image: Western blot analysis of extracts from various cell types using TCF4 (C48H11) Rabbit mAb.)
Application Data
(Image: Western blot analysis of extracts from various cell types using TCF4 (C48H11) Rabbit mAb.)
Related Product Information for anti-TCF4 antibody
LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors which consists of the following: Lymphoid enhancer factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3 and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1/TCF bind to Wnt response elements to provide a docking site for b-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1/TCF proteins are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).
TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting studies indicate that TCF4 is required to maintain the crypt stem cells of the small intestine (6,7). TCF4 has several splicing isoforms that are expressed differentially in tissues and during cancer progression (8,9). Studies also indicate that a variant of the TCF4 gene confers an increased risk of type 2 diabetes (10).
TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting studies indicate that TCF4 is required to maintain the crypt stem cells of the small intestine (6,7). TCF4 has several splicing isoforms that are expressed differentially in tissues and during cancer progression (8,9). Studies also indicate that a variant of the TCF4 gene confers an increased risk of type 2 diabetes (10).
Product Categories/Family for anti-TCF4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
transcription factor 4 isoform c
NCBI Official Synonym Full Names
transcription factor 4
NCBI Official Symbol
TCF4
NCBI Official Synonym Symbols
E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
NCBI Protein Information
transcription factor 4
UniProt Protein Name
Transcription factor 4
UniProt Gene Name
TCF4
UniProt Synonym Gene Names
BHLHB19; ITF2; SEF2; TCF-4; bHLHb19; ITF-2; SEF-2
UniProt Entry Name
ITF2_HUMAN
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Product Notes
The TCF4 tcf4 (Catalog #AAA76492) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The TCF4 (C48H11), Monoclonal Antibody, Rabbit reacts with Chicken, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TCF4 (C48H11) can be used in a range of immunoassay formats including, but not limited to, IP (Immunoprecipitation), WB (Western Blot). Researchers should empirically determine the suitability of the TCF4 tcf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TCF4 (C48H11), Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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