IHC (Immunohistochemisry)
(PTP1B Antibody-Human Pancreas, Islet of Langerhans: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human PTP1B Polyclonal Antibody | anti-PTPN1 antibody
PTP1B Rabbit anti-Human Polyclonal Antibody
Gene Names
PTPN1; PTP1B
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PTP1B, Antibody; PTP1B Rabbit anti-Human Polyclonal Antibody; PathPlus PTP1B Antibody; PTPN1; PTP1B; PTP-1B; PTPase 1B; anti-PTPN1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PTPN1 antibody
IHC (Immunohistochemistry)
Target
Human PTP1B
Immunogen
LP-10976, synthetic peptide
Conjugation
Unconjugated
Family
Protein Phosphatase
Subfamily
NT1
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemisry)
(PTP1B Antibody-Human Pancreas, Islet of Langerhans: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(PTP1B Antibody-Human Pancreas, Islet of Langerhans: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PTP1B Antibody-Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PTP1B Antibody-Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PTP1B Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PTP1B Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-PTPN1 antibody
PTP1B antibody is an unconjugated rabbit polyclonal antibody to PTP1B from human. Validated for IHC.
PTPN1 (PTP1B) is the founding member of the protein tyrosine phosphatase (PTP) family of proteins, which catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN1 dephosphorylates the EGFR, JAK2 and TYK2 kinases, implicating PTPN1 in cell growth control and cell response to interferon stimulation. PTPN1 has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. It is also thought to contribute to breast tumorigenesis. Because of this, PTPN1 is a putative therapeutic target for type 2 diabetes and some forms of cancer.
PTPN1 (PTP1B) is the founding member of the protein tyrosine phosphatase (PTP) family of proteins, which catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN1 dephosphorylates the EGFR, JAK2 and TYK2 kinases, implicating PTPN1 in cell growth control and cell response to interferon stimulation. PTPN1 has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. It is also thought to contribute to breast tumorigenesis. Because of this, PTPN1 is a putative therapeutic target for type 2 diabetes and some forms of cancer.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Cancer Res. 67 (6): 2420 -4, PMID: 17347513; J. Med. Chem. 53 (6): 2333 -44, PMID: 20000419;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,967 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 1
NCBI Official Symbol
PTPN1
NCBI Official Synonym Symbols
PTP1B
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 1
UniProt Gene Name
PTPN1
UniProt Synonym Gene Names
PTP1B; PTP-1B
UniProt Entry Name
PTN1_HUMAN
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Product Notes
The PTPN1 ptpn1 (Catalog #AAA163014) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTP1B Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTP1B can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PTPN1 ptpn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTP1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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