IHC (Immunohiostchemistry)
(PDGFRA/PDGFR Alpha Antibody-Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human PDGFRA/PDGFR Alpha Polyclonal Antibody | anti-PDGFRA antibody
PDGFRA/PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Gene Names
PDGFRA; CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
Reactivity
Human
Applications
Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
PDGFRA/PDGFR Alpha, Antibody; PDGFRA/PDGFR Alpha Rabbit anti-Human Polyclonal Antibody; PathPlus PDGFRA/PDGFR Alpha Antibody; PDGFRA; CD140A; CD140a antigen; PDGFalphaR; PDGFR2; PDGFRalpha; AlphaPDGFR; RHEPDGFRA; PDGF receptor alpha; PDGFR-2; PDGFRA/BCR fusion; APDGFR; Pdgf alpha-receptor; PDGF-R-alpha; PDGFR-alpha; anti-PDGFRA antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PDGFRA antibody
IHC (Immunohistochemistry)
Target
Human PDGFRA/PDGFR Alpha
Immunogen
LP-10940, synthetic peptide
Conjugation
Unconjugated
Family
Protein Kinase
Subfamily
PDGF Receptor
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohiostchemistry)
(PDGFRA/PDGFR Alpha Antibody-Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(PDGFRA/PDGFR Alpha Antibody-Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PDGFRA/PDGFR Alpha Antibody-Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(PDGFRA/PDGFR Alpha Antibody-Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-PDGFRA antibody
PDGFR Alpha antibody is an unconjugated rabbit polyclonal antibody to PDGFR Alpha (PDGFRA) from human. Validated for IHC.
PDGFRA is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival, cell migration, chemotaxis in wound healing, and platelet activation and aggregation. Depending on the context, it promotes or inhibits cell proliferation and cell migration. It plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells and is required for normal skeleton development, the development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and the normal development of intestinal villi. In cancer, PDGFRA is overexpressed in gliomas, gastrointestinal stromal tumors (GIST), and ovarian, prostate, colon, lung, breast, bone and skin cancers. PDGFRA expression in ovarian cancer and chondrosarcoma is associated with shorter survival. In immunohistochemistry of normal tissue, PDGFRA is widely expressed throughout the body.
PDGFRA is a tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival, cell migration, chemotaxis in wound healing, and platelet activation and aggregation. Depending on the context, it promotes or inhibits cell proliferation and cell migration. It plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells and is required for normal skeleton development, the development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and the normal development of intestinal villi. In cancer, PDGFRA is overexpressed in gliomas, gastrointestinal stromal tumors (GIST), and ovarian, prostate, colon, lung, breast, bone and skin cancers. PDGFRA expression in ovarian cancer and chondrosarcoma is associated with shorter survival. In immunohistochemistry of normal tissue, PDGFRA is widely expressed throughout the body.
References
J Cell Physiol. 1994 Feb; 158(2):381-9, PMID: 8106574; J Histochem Cytochem. 2016 Dec; 64(12): 785 -810, PMID: 27837159; Am J Surg Pathol 2001;25:1520; Sci Rep. 2015 Dec 7;5:17948, PMID: 26639755
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
122,670 Da
NCBI Official Full Name
platelet-derived growth factor receptor alpha
NCBI Official Synonym Full Names
platelet-derived growth factor receptor, alpha polypeptide
NCBI Official Symbol
PDGFRA
NCBI Official Synonym Symbols
CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
NCBI Protein Information
platelet-derived growth factor receptor alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophi
UniProt Protein Name
Platelet-derived growth factor receptor alpha
UniProt Gene Name
PDGFRA
UniProt Synonym Gene Names
PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2
UniProt Entry Name
PGFRA_HUMAN
Similar Products
Product Notes
The PDGFRA pdgfra (Catalog #AAA162994) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDGFRA/PDGFR Alpha Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PDGFRA/PDGFR Alpha can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the PDGFRA pdgfra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDGFRA/PDGFR Alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.