Rabbit FGFR3 Polyclonal Antibody | anti-FGFR3 antibody

FGFR3 Antibody

Cat. Num. AAA40525

• Gene Names: FGFR3; ACH; CEK2; JTK4; CD333; HSFGFR3EX
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: FGFR3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: FGFR3, Antibody; FGFR3 Antibody; FGFR3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; Fibroblast growth factor receptor 3; FGFR-3; fibroblast growth factor receptor 3; anti-FGFR3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.
• Purity/Purification: FGFR3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 808

• Applicable Applications for anti-FGFR3 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.
• Buffer: FGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of FGFR3 in rat brain tissue with FGFR3 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of FGFR3 in rat brain tissue with FGFR3 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 antibody at (A) 0.5 and (B) 1 μg/mL.)

Related Product Information for anti-FGFR3 antibody

FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).

NCBI and Uniprot Product Information

• NCBI GI #: 254028242
• NCBI GeneID: 2261
• NCBI Accession #: NP_001156685
• NCBI GenBank Nucleotide #: NM_001163213.1
• UniProt Accession #: P22607; Q14308; Q16294; Q16608; Q59FL9; D3DVP9; D3DVQ0
• Molecular Weight: Predicted: 89 kDa; ; Observed: 9+2; 98 kDa
• NCBI Official Full Name: fibroblast growth factor receptor 3 isoform 3
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 3
• NCBI Official Symbol: FGFR3
• NCBI Official Synonym Symbols: ACH; CEK2; JTK4; CD333; HSFGFR3EX
• NCBI Protein Information: fibroblast growth factor receptor 3; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; fibroblast growth factor receptor 3 variant 4
• UniProt Protein Name: Fibroblast growth factor receptor 3
• UniProt Gene Name: FGFR3
• UniProt Synonym Gene Names: JTK4; FGFR-3
• UniProt Entry Name: FGFR3_HUMAN