Rabbit anti-Human Caspase-10 Polyclonal Antibody | anti-CASP10 antibody

Caspase-10 Antibody

Cat. Num. AAA39661

• Gene Names: CASP10; MCH4; ALPS2; FLICE2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Caspase-10 Antibody is Antibody is DEAE purified.
• Synonyms: Caspase-10, Antibody; Caspase-10 Antibody; Caspase-10; MCH4; Apoptotic protease Mch-4; CASP-10; caspase 10, apoptosis-related cysteine peptidase; anti-CASP10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Antibody only recognizes FLICE2 form of caspase-10.
• Purity/Purification: Caspase-10 Antibody is Antibody is DEAE purified.
• Form/Format: Liquid
• Sequence Length: 273

• Applicable Applications for anti-CASP10 antibody: WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: Caspase-10 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Caspase-10.
• Buffer: Caspase-10 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Caspase-10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of Casp10 in Hela cells with Caspase 10 antibody at 5 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of Casp10 in Hela cells with Caspase 10 antibody at 20 μg/mL.Green: Caspase-10 Antibody (1128)Blue: DAPI staining)

WB (Western Blot)

(Western blot analysis of caspase-10 in HeLa (H), Jurkat (J), A431 (A), K562 (K) whole cell lysates with Caspase-10 antibody at 1 μg/mL.)

Related Product Information for anti-CASP10 antibody

Caspase-10 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.

NCBI and Uniprot Product Information

• NCBI GI #: 4731237
• NCBI GeneID: 843
• UniProt Accession #: Q92851; Q68HC0; Q6KF62; Q6KF63; Q8IUP5; Q8WYQ8; Q99845; Q9Y2U6; Q9Y2U7
• Molecular Weight: 28,364 Da
• NCBI Official Full Name: caspase-10/c
• NCBI Official Synonym Full Names: caspase 10, apoptosis-related cysteine peptidase
• NCBI Official Symbol: CASP10
• NCBI Official Synonym Symbols: MCH4; ALPS2; FLICE2
• NCBI Protein Information: caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2
• UniProt Protein Name: Caspase-10
• UniProt Gene Name: CASP10
• UniProt Synonym Gene Names: MCH4; CASP-10; FLICE2
• UniProt Entry Name: CASPA_HUMAN