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IHC (Immunohistochemistry)
(Anti-Annexin A1 Picoband antibody, AAA46052-4.JPGIHC(P): Rat Lung Tissue)
Rabbit Annexin A1 Polyclonal Antibody | anti-ANXA1 antibody
Anti-Annexin A1 Antibody
Gene Names
ANXA1; ANX1; LPC1
Reactivity
Human, Mouse, Rat. No cross reactivity with other proteins.
Applications
Immunohistochemistry, Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
Annexin A1, Antibody; Anti-Annexin A1 Antibody; Annexin 1 antibody; Annexin A1 antibody; Annexin I (lipocortin I) antibody; Annexin I antibody; Annexin-1 antibody; AnnexinA1 antibody; AnnexinI antibody; ANX 1 antibody; ANX A1 antibody; ANX1 antibody; ANXA 1 antibody; ANXA1 antibody; ANXA1 protein antibody; ANXA1_HUMAN antibody; Calpactin 2 antibody; Calpactin II antibody; Calpactin-2 antibody; CalpactinII antibody; Chromobindin 9 antibody; Chromobindin-9 antibody; Chromobindin9 antibody; Lipocortin 1 antibody; Lipocortin I antibody; Lipocortin1 antibody; LipocortinI antibody; LPC 1 antibody; LPC1 antibody; p35 antibody; Phospholipase A2 inhibitory protein antibody; annexin A1; anti-ANXA1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat. No cross reactivity with other proteins.
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
346
Applicable Applications for anti-ANXA1 antibody
IHC (Immunohistochemistry), IHC (Immunohistochemistry), WB (Western Blot)
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E.coli-derived human Annexin A1 recombinant protein (Position: A2-N346). Human Annexin A1 shares 88% and 89% amino acid (aa) sequences identity with mouse and rat Annexin A1, respectively.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohistochemistry)
(Anti-Annexin A1 Picoband antibody, AAA46052-4.JPGIHC(P): Rat Lung Tissue)
IHC (Immunohistochemistry)
(Anti-Annexin A1 Picoband antibody, AAA46052-4.JPGIHC(P): Rat Lung Tissue)
IHC (Immunohistochemisry)
(Anti-Annexin A1 Picoband antibody, AAA46052-3.JPGIHC(P): Human Tonsil Tissue)
IHC (Immunohistochemisry)
(Anti-Annexin A1 Picoband antibody, AAA46052-3.JPGIHC(P): Human Tonsil Tissue)
Application Data
(Anti-Annexin A1 Picoband antibody, AAA46052-2.jpgAll lanes: Anti AnnexinA1 (AAA46052) at 0.5ug/mlLane 1: HEPG2 Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: U87 Whole Cell Lysate at 40ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: SMMC Whole Cell Lysate at 40ugLane 6: SW620 Whole Cell Lysate at 40ugLane 7: COLO320 Whole Cell Lysate at 40ugLane 8: A549 Whole Cell Lysate at 40ugLane 9: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Application Data
(Anti-Annexin A1 Picoband antibody, AAA46052-2.jpgAll lanes: Anti AnnexinA1 (AAA46052) at 0.5ug/mlLane 1: HEPG2 Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: U87 Whole Cell Lysate at 40ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: SMMC Whole Cell Lysate at 40ugLane 6: SW620 Whole Cell Lysate at 40ugLane 7: COLO320 Whole Cell Lysate at 40ugLane 8: A549 Whole Cell Lysate at 40ugLane 9: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Application Data
(Anti-Annexin A1 Picoband antibody, AAA46052-1.jpgAll lanes: Anti AnnexinA1 (AAA46052) at 0.5ug/mlWB: Recombinant Human AnnexinA1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD)
Application Data
(Anti-Annexin A1 Picoband antibody, AAA46052-1.jpgAll lanes: Anti AnnexinA1 (AAA46052) at 0.5ug/mlWB: Recombinant Human AnnexinA1 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD)
Related Product Information for anti-ANXA1 antibody
Description: Rabbit IgG polyclonal antibody for Annexin A1(ANXA1) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat.
Background: ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.
Background: ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38,714 Da
NCBI Official Full Name
annexin A1
NCBI Official Synonym Full Names
annexin A1
NCBI Official Symbol
ANXA1
NCBI Official Synonym Symbols
ANX1; LPC1
NCBI Protein Information
annexin A1; annexin-1; calpactin-2; calpactin II; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein
UniProt Protein Name
Annexin A1
UniProt Gene Name
ANXA1
UniProt Synonym Gene Names
ANX1; LPC1
UniProt Entry Name
ANXA1_HUMAN
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Product Notes
The ANXA1 anxa1 (Catalog #AAA46052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Annexin A1 Antibody reacts with Human, Mouse, Rat. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Annexin A1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the ANXA1 anxa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Annexin A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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