IL-6 receptor Recombinant Antibody | IL6R recombinant antibody
Anti-IL-6 receptor [rhPM-1 (Tocilizumab)]
Reactivity
Human
Applications
ELISA
Purity
PurifiedProtein A Affinity Purified
Synonyms
IL-6 receptor, Recombinant Antibody; Anti-IL-6 receptor [rhPM-1 (Tocilizumab)]; MRA; atlizumab; IL6R recombinant antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG, kappa
Clone Number
rhPM-1 (Tocilizumab)
Specificity
Tocilizumab binds specifically to both the membrane bound and soluble forms of humanIL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) andinterleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokinethat regulates cell growth and differentiation and plays an important role in immune response.
Purity/Purification
Purified
Protein A Affinity Purified
Protein A Affinity Purified
Form/Format
PBS only with 0.02% Proclin 300.
Concentration
1 mg/ml (varies by lot)
Applicable Applications for IL6R recombinant antibody
IA (Inhibition Assay), ELISA
Immunogen
This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
Antigen
IL-6 receptor
Note
Describes the design and construction of reshaped human AUKl2-20 antibodies which bind specifically to human IL-6R.
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Preparation and Storage
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Related Product Information for IL6R recombinant antibody
Recombinant monoclonal antibody to IL-6 receptor. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody rhPM-1(Tocilizumab).
Product Categories/Family for IL6R recombinant antibody
References
Sato et al. Mol Immunol. 1994 Apr;31(5):371-81. PMID:8152440
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Product Notes
The IL6R (Catalog #AAA71981) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL-6 receptor [rhPM-1 (Tocilizumab)] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-6 receptor can be used in a range of immunoassay formats including, but not limited to, IA (Inhibition Assay), ELISA. Researchers should empirically determine the suitability of the IL6R for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-6 receptor, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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